[HTML][HTML] Phenolic metabolites as therapeutic in inflammation and neoplasms: Molecular pathways explaining their efficacy

W Liu, X Cui, Y Zhong, R Ma, B Liu, Y **a - Pharmacological research, 2023 - Elsevier
Polyphenols, also known as phenolic compounds, are chemical substances containing
aromatic rings as well as at least two hydroxyl groups. Natural phenolic compounds exist …

Ferroptosis and NRF2: an emerging battlefield in the neurodegeneration of Alzheimer's disease

DJR Lane, B Metselaar, M Greenough… - Essays in …, 2021 - portlandpress.com
Ferroptosis is an iron-and lipid peroxidation-dependent cell death modality and emerging
evidence indicates that ferroptosis has great explanatory potential for neuronal loss and …

Pharmacological activities and pharmacokinetics of liquiritin: a review

J Qin, J Chen, F Peng, C Sun, Y Lei, G Chen… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance Liquiritin is a flavonoid derived from Radix et Rhizoma
Glycyrrhizae, which is a widely used traditional Chinese medicine with the effects of …

Natural products attenuate PI3K/Akt/mTOR signaling pathway: A promising strategy in regulating neurodegeneration

S Fakhri, A Iranpanah, MM Gravandi, SZ Moradi… - Phytomedicine, 2021 - Elsevier
Background As common, progressive, and chronic causes of disability and death,
neurodegenerative diseases (NDDs) significantly threaten human health, while no effective …

Molecular mechanisms behind safranal's toxicity to HepG2 cells from dual omics

DR Nelson, AA Hrout, AS Alzahmi, A Chaiboonchoe… - Antioxidants, 2022 - mdpi.com
The spice saffron (Crocus sativus) has anticancer activity in several human tissues, but the
molecular mechanisms underlying its potential therapeutic effects are poorly understood …

Effects of polyphenols on oxidative stress, inflammation, and interconnected pathways during spinal cord injury

S Fakhri, F Abbaszadeh, SZ Moradi… - Oxidative medicine …, 2022 - Wiley Online Library
Despite the progression in targeting the complex pathophysiological mechanisms of
neurodegenerative diseases (NDDs) and spinal cord injury (SCI), there is a lack of effective …

Sulfur compounds: From plants to humans and their role in chronic disease prevention

CR Hill, A Shafaei, L Balmer, JR Lewis… - Critical Reviews in …, 2023 - Taylor & Francis
Sulfur is essential for the health of plants and is an indispensable dietary component for
human health and disease prevention. Its incorporation into our food supply is heavily reliant …

The link between oxidative stress, mitochondrial dysfunction and neuroinflammation in the pathophysiology of Alzheimer's disease: therapeutic implications and future …

MC Jurcău, FL Andronie-Cioara, A Jurcău, F Marcu… - Antioxidants, 2022 - mdpi.com
Alzheimer's disease (AD), the most common form of dementia, has increasing incidence,
increasing mortality rates, and poses a huge burden on healthcare. None of the currently …

The role of the transcription factor Nrf2 in Alzheimer's disease: therapeutic opportunities

LM De Plano, G Calabrese, MG Rizzo, S Oddo… - Biomolecules, 2023 - mdpi.com
Alzheimer's disease (AD) is a common neurodegenerative disorder that affects the elderly.
One of the key features of AD is the accumulation of reactive oxygen species (ROS), which …

[HTML][HTML] Oxyphylla A ameliorates cognitive deficits and alleviates neuropathology via the Akt-GSK3β and Nrf2-Keap1-HO-1 pathways in vitro and in vivo murine …

Y Bian, Y Chen, X Wang, G Cui, COL Ung, JH Lu… - Journal of Advanced …, 2021 - Elsevier
Introduction Alzheimer's disease (AD) is a progressive brain disorder, and one of the most
common causes of dementia and amnesia. Due to the complex pathogenesis of AD, the …