NMDA receptors (NMDARs) are glutamate-gated ion channels and are crucial for neuronal
communication. NMDARs form tetrameric complexes that consist of several homologous …

Zinc is involved in a variety of biological processes, as a structural, catalytic, and intracellular
and intercellular signaling component. Thus zinc homeostasis is tightly controlled at the …

Chronic pain, as a stress state, is one of the critical factors for determining depression, and
their coexistence tends to further aggravate the severity of both disorders. Unfortunately …

After nerve injury maladaptive changes can occur in injured sensory neurons and along the
entire nociceptive pathway within the CNS, which may lead to spontaneous pain or pain …

Nearly sixty years ago Fredrich Timm developed a histochemical technique that revealed a
rich reserve of free zinc in distinct regions of the brain. Subsequent electron microscopy …

N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely
expressed in the central nervous system that play key role in brain development and …

NMDA receptors are tetrameric ligand-gated ion channels comprised of GluN1, GluN2, and
GluN3 subunits. Two different GluN2 subunits have been identified in most NMDA receptor …

Our understanding of the roles played by zinc in the physiological and pathological
functioning of the brain is rapidly expanding. The increased availability of genetically …

NMDA receptor (NMDAR) dysfunction has emerged as a common theme in several major
nervous system disorders, including ischemic brain injury, chronic neurodegenerative …

NMDA receptors are preeminent neurotransmitter-gated channels in the CNS, which
respond to glutamate in a manner that integrates multiple external and internal cues. They …