Ferroptosis, a unique modality of cell death with mechanistic and morphological differences
from other cell death modes, plays a pivotal role in regulating tumorigenesis and offers a …

Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central
nervous system afflicting nearly three million individuals worldwide. Neuroimmune …

Chronic active lesions (CAL) are an important manifestation of chronic inflammation in
multiple sclerosis and have implications for non-relapsing biological progression. In recent …

Chronic low-grade inflammation and neuronal deregulation are two components of a
smoldering disease activity that drives the progression of disability in people with multiple …

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) that
results in significant neurodegeneration in the majority of those affected and is a common …

Importance Emerging evidence suggests that progression independent of relapse activity
(PIRA) is a substantial contributor to long-term disability accumulation in relapsing-remitting …

Background The omicron BA. 1 bivalent booster is used globally. Previous open-label
studies of the omicron BA. 1 (Moderna mRNA-1273.214) booster showed superior …

Background Chronic active lesions (CAL) in multiple sclerosis (MS) have been observed
even in patients taking high-efficacy disease-modifying therapy, including B-cell depletion …

Multiple sclerosis is a chronic, inflammatory, and neurodegenerative disease of the central
nervous system and a major cause of neurological disability in young adults. Its prevalence …

Despite therapeutic suppression of relapses, multiple sclerosis (MS) patients often
experience subtle deterioration, which extends beyond the definition of “progression …