Crown ethers are heterocycles that, in their simplest form, are cyclic oligomers of dioxane.
The essential repeating unit of any simple crown ether is ethyleneoxy, ie,-CH2CH2O-, which …

The compelling chemical goal of modeling protein channel behavior has led to synthetic
compounds that are true ion channels. Although they largely lack the selectivity and …

Single crystals of a lipophilic G-quadruplex formed by 5 '-tert-butyl-dimethylsilyl-2 ', 3 ',-di-O-
isopropylidene G 2 were obtained from a CH3CN solution containing potassium picrate and …

The ion transport activity of calix [4] arene tetrabutylamide 1, 3-alt 2 was studied in
liposomes, planar lipid bilayers, and HEK-293 cells. These experiments, when considered …

The binding of copper (II) ions to membrane-bound synthetic receptors has been
investigated. Complexation fitted a 4: 1 receptor: copper (II) model, and the observed …

Design, synthesis, and structural and functional studies of rigid-rod ionophores of different
axial electrostatic asymmetry are reported. The employed design strategy emphasized …

The X-ray crystal structures of biological ion channels are exquisitely complex, but not all
natural products capable of forming ion-conducting channels are equally elaborate …

Crown ether-based synthetic cation conducting channels called hydraphiles show clear
ionophoretic activity in phospholipid vesicles. These compounds are shown to be active …

We report the synthesis and the functional studies of multiple crown α-helical peptides
designed to form artificial ion channels. The approach combines the versatility of solid phase …

The concept of channels has been with us more than a century. For half a century, biologists
have studied the remarkable workings of protein and peptide channels that permit various …