Cyclic peptides are fascinating molecules abundantly found in nature and exploited as
molecular format for drug development as well as other applications, ranging from research …

Approximately 75% of all disease-relevant human proteins, including those involved in
intracellular protein–protein interactions (PPIs), are undruggable with the current drug …

Autophagy is a self-eating catabolic pathway that contributes to liver homeostasis through its
role in energy balance and in the quality control of the cytoplasm, by removing misfolded …

Peptide-based supramolecular hydrogels have shown great promise as drug delivery
systems (DDSs) because of their excellent biocompatibility, biodegradability, biological …

Proteolysis Targeting Chimeras (PROTACs) are heterobifunctional degraders that
specifically eliminate targeted proteins by hijacking the ubiquitin-proteasome system (UPS) …

Photothermal therapy efficiently ablates tumors via hyperthermia but inevitably induces
serious side effects including thermal damage to normal tissues, inflammations and …

The migration of neutrophils from the blood circulation to sites of infection or injury is a key
immune response and requires the breaching of endothelial cells (ECs) that line the inner …

Naturally occurring peptides with high membrane permeability often have ester bonds on
their backbones. However, the impact of amide-to-ester substitutions on the membrane …

Protein–protein interactions (PPIs) are implicated in the majority of cellular processes by
enabling and regulating the function of individual proteins. Thus, PPIs represent high-value …

The LC3/GABARAP family of proteins is involved in nearly every stage of autophagy.
Inhibition of LC3/GABARAP proteins is a promising approach to blocking autophagy, which …