C5aR2 activation broadly modulates the signaling and function of primary human macrophages

XX Li, RJ Clark, TM Woodruff - The Journal of Immunology, 2020 - journals.aai.org
The complement activation fragment C5a is a potent proinflammatory mediator that is
increasingly recognized as an immune modulator. C5a acts through two C5a receptors …

The “C3aR antagonist” SB290157 is a partial C5aR2 agonist

XX Li, V Kumar, RJ Clark, JD Lee… - Frontiers in …, 2021 - frontiersin.org
Innate immune complement activation generates the C3 and C5 protein cleavage products
C3a and C5a, defined classically as anaphylatoxins. C3a activates C3aR, while C5a …

[HTML][HTML] respiratory tract irritation Menu

XX Li, RJ Clark, TM Woodruff - piperlonguminechemical.com
The complement activation fragment C5a is a potent proinflammatory mediator that is
increasingly recognized as an immune modulator. C5a acts through two C5a receptors …