Inflammation, a process intimately linked to renal disease, can be defined as a complex
network of interactions between renal parenchymal cells and resident immune cells, such as …

The phenotypic heterogeneity and functional diversity of macrophages confer on them
complexed roles in the development and progression of kidney diseases. After kidney injury …

Background Resident macrophages regulate homeostatic and disease processes in
multiple tissues, including the kidney. Despite having well defined markers to identify these …

Fibrosis is a pathophysiological process of wound repair that leads to the deposit of
connective tissue in the extracellular matrix. This complication is mainly associated with …

Cardiomyocyte apoptosis in response to inflammation is a primary cause of myocardial
ischemia-reperfusion injury (IRI). Nuclear factor erythroid 2 like 2 (Nrf2) reportedly plays an …

Renal fibrosis is a common pathological manifestation in various chronic kidney diseases.
Inflammation plays a central role in renal fibrosis development. Owing to their significant …

Nuclear factor κ-B (NFκB) is activated in iPSC-cardiac myocytes from patients with
arrhythmogenic cardiomyopathy (ACM) under basal conditions, and inhibition of NFκB …

Background α-Viniferin, the major constituent of the roots of Caragana sinica (Buc'hoz)
Rehder with a trimeric resveratrol oligostilbenoid skeleton, was demonstrated to possess a …

Following acute myocardial ischemia reperfusion (MIR), macrophages infiltrate damaged
cardiac tissue and alter their polarization phenotype to respond to acute inflammation and …

Abstract Experimental autoimmune-orchitis (EAO), a rodent model of chronic testicular
inflammation and fibrosis, replicates pathogenic changes seen in some cases of human …