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Epigenetics-targeted drugs: Current paradigms and future challenges
W Dai, X Qiao, Y Fang, R Guo, P Bai, S Liu… - … and Targeted Therapy, 2024 - nature.com
Epigenetics governs a chromatin state regulatory system through five key mechanisms: DNA
modification, histone modification, RNA modification, chromatin remodeling, and non-coding …
modification, histone modification, RNA modification, chromatin remodeling, and non-coding …
Insights into epigenetic patterns in mammalian early embryos
Mammalian fertilization begins with the fusion of two specialized gametes, followed by major
epigenetic remodeling leading to the formation of a totipotent embryo. During the …
epigenetic remodeling leading to the formation of a totipotent embryo. During the …
Mouse totipotent stem cells captured and maintained through spliceosomal repression
Since establishment of the first embryonic stem cells (ESCs), in vitro culture of totipotent cells
functionally and molecularly comparable with in vivo blastomeres with embryonic and …
functionally and molecularly comparable with in vivo blastomeres with embryonic and …
scm6A-seq reveals single-cell landscapes of the dynamic m6A during oocyte maturation and early embryonic development
H Yao, CC Gao, D Zhang, J Xu, G Song, X Fan… - Nature …, 2023 - nature.com
Abstract N 6-methyladenosine (m6A) has been demonstrated to regulate RNA metabolism
and various biological processes, including gametogenesis and embryogenesis. However …
and various biological processes, including gametogenesis and embryogenesis. However …
The first two blastomeres contribute unequally to the human embryo
Retrospective lineage reconstruction of humans predicts that dramatic clonal imbalances in
the body can be traced to the 2-cell stage embryo. However, whether and how such clonal …
the body can be traced to the 2-cell stage embryo. However, whether and how such clonal …
Profiling and functional characterization of maternal mRNA translation during mouse maternal-to-zygotic transition
Translational regulation plays an important role in gene expression and function. Although
the transcriptional dynamics of mouse preimplantation embryos have been well …
the transcriptional dynamics of mouse preimplantation embryos have been well …
RNA damage compartmentalization by DHX9 stress granules
Biomolecules incur damage during stress conditions, and damage partitioning represents a
vital survival strategy for cells. Here, we identified a distinct stress granule (SG), marked by …
vital survival strategy for cells. Here, we identified a distinct stress granule (SG), marked by …
Principles and mechanisms of asymmetric cell division
Asymmetric cell division (ACD) is an evolutionarily conserved mechanism used by
prokaryotes and eukaryotes alike to control cell fate and generate cell diversity. A detailed …
prokaryotes and eukaryotes alike to control cell fate and generate cell diversity. A detailed …
LncRNA INHEG promotes glioma stem cell maintenance and tumorigenicity through regulating rRNA 2'-O-methylation
Glioblastoma (GBM) ranks among the most lethal of human cancers, containing glioma stem
cells (GSCs) that display therapeutic resistance. Here, we report that the lncRNA INHEG is …
cells (GSCs) that display therapeutic resistance. Here, we report that the lncRNA INHEG is …
Principles of self-organization of the mammalian embryo
Early embryogenesis is a conserved and self-organized process. In the mammalian embryo,
the potential for self-organization is manifested in its extraordinary developmental plasticity …
the potential for self-organization is manifested in its extraordinary developmental plasticity …