Cell-directed changes in the ligand-binding affinity ('activation') of integrins regulate cell
adhesion and migration, extracellular matrix assembly and mechanotransduction, thereby …

Regulation of cell-cell and cell-matrix interaction is essential for the normal physiology of
metazoans and is important in many diseases. Integrin adhesion receptors can rapidly …

Tetraspanins play critical roles in various physiological processes, ranging from cell
adhesion to virus infection. The members of the tetraspanin family have four membrane …

Heterodimeric integrin adhesion receptors regulate cell migration, survival and
differentiation in metazoa by communicating signals bi‐directionally across the plasma …

Helical integral membrane proteins share several structural determinants that are widely
conserved across their universe. The discovery of common motifs has furthered our …

Platelet aggregation is a critical event in thrombus formation and thus has extensive
involvement in physiological and pathological processes. The aggregation response …

Transmembrane (TM) helices of integral membrane proteins can facilitate strong and
specific noncovalent protein–protein interactions. Mutagenesis and structural analyses have …

Integrins constitute an important class of cell adhesion receptors responsible not only for cell-
matrix adhesion but also for signaling bidirectionally across the membrane. Integrins are …

Integrin α IIb β 3 plays a critical role in platelet aggregation, a central response in
hemostasis and thrombosis. This function of α IIb β 3 depends upon a transition from a …

A variety of methods exist for the design or selection of antibodies and other proteins that
recognize the water-soluble regions of proteins; however, companion methods for targeting …