This chapter reviews how allosteric (heterotrophic) effectors and natural mutations impact
hemoglobin (Hb) primary physiological function of oxygen binding and transport. First, an …

Sickle cell disease (SCD) is a group of inherited disorders caused by mutations in HBB,
which encodes haemoglobin subunit β. The incidence is estimated to be between 300,000 …

Membrane sphingolipids are metabolized to sphingosine-1-phosphate (S1P), a bioactive
lipid mediator that regulates many processes in vertebrate development, physiology, and …

For over 100 years, clinicians and scientists have been unravelling the consequences of the
A to T substitution in the β-globin gene that produces haemoglobin S, which leads to the …

Abstract Sphingosine-1-phosphate (S1P), a potent signalling lipid secreted by red blood
cells and platelets,, plays numerous biologically significant roles,,,. However, the identity of …

Abstract Sphingosine-1-phosphate (S1P) is a bioactive signalling lipid highly enriched in
mature erythrocytes, with unknown functions pertaining to erythrocyte physiology. Here by …

Sphingosine kinases (isoforms SK1 and SK2) catalyse the formation of a bioactive lipid,
sphingosine 1-phosphate (S1P). S1P is a well-established ligand of a family of five S1P …

The central nervous system is characterized by a high content of sphingolipids and by a high
diversity in terms of different structures. Stage-and cell-specific sphingolipid metabolism and …

In cell and molecular biology, metabolism is the only system that can be fully simulated at
genome scale. Metabolic systems biology offers powerful abstraction tools to simulate all …

Background: High altitude is a challenging condition caused by insufficient oxygen supply.
Inability to adjust to hypoxia may lead to pulmonary edema, stroke, cardiovascular …