[PDF][PDF] Synthesis and biological evaluation of thieno [2, 3-d] pyrimidine derivatives for anti-inflammatory, analgesic and ulcerogenic activity

AR El-Gazzar, H Hussein, H Hafez - Acta Pharmaceutica, 2007 - intapi.sciendo.com
5-Methyl-6-phenyl-2-thioxothieno [2, 3-d] pyrimidone derivative (2) reacted with hydrazonoyl
chloride derivatives to afford triazolothienopyrimidones 4a–f. Also, acetone--1-(2-amino-5 …

Design, molecular modeling and anticancer evaluation of thieno [2, 3-d] pyrimidine derivatives as inhibitors of topoisomerase II

SA El-Metwally, AK Khalil, WM El-Sayed - Bioorganic Chemistry, 2020 - Elsevier
Abstract Synthesis of 4-(3, 5-dimethyl-1H-pyrazol-1-yl)-5, 6, 7, 8-tetrahydrobenzo [4, 5]
thieno [2, 3-d] pyrimidine 1 and its functionalized reactions as nucleophile with various …

[PDF][PDF] Synthesis and antimicrobial evaluation of some new thienopyrimidine derivatives

MH Bhuiyan, KM Rahman, K Hossain… - ACTA …, 2006 - core.ac.uk
Reaction of heteroaromatic o-aminonitrile with ethyl N--[bis (methylthio) methylene] amino
acetate resulted in annelation of a thieno [3, 2-e] imidazo [1, 2-c] pyrimidine moiety in a one …

[HTML][HTML] Synthesis and characterization of novel Schiff bases containing pyrimidine unit

JH Tomma, MS Khazaal, AH Al-Dujaili - Arabian Journal of chemistry, 2014 - Elsevier
The work involves synthesis of novel Schiff base derivatives containing a pyrimidine unit
starting with chalcones. 4-Aminoacetophenone was reacted with 4-nitrobenzaldehyde or 4 …

Synthesis of New Fused Thienopyrimidines Derivatives as Anti‐inflammatory Agents

MS Tolba, M Ahmed… - Journal of …, 2018 - Wiley Online Library
5‐Amino‐2‐(p‐tolylamino)‐4‐phenylthieno [2, 3‐d] pyrimidine‐6‐carbonitrile 9, which was
synthesized by an innovative method, was used as a versatile precursor for synthesizing …

Eco‐friendly synthesis of novel pyrimidine derivatives as potential anticancer agents

EM Abbass, AK Khalil… - Journal of Heterocyclic …, 2020 - Wiley Online Library
Herein, a rapid and highly efficient method for the synthesis of a new series of pyrimidine
derivatives was demonstrated. The strategy was emanated from the reaction of hydrazinyl …

Design, synthesis, and anticancer evaluation of novel imidazo [1, 2-c] thieno [3, 2-e] pyrimidin derivatives

F Alizadeh-Bami, H Mehrabi, F Safari - Tetrahedron, 2023 - Elsevier
Derivatives of a novel heterocyclic system ethyl 2-(2-(aryl)-9-(aryl) imidazo [1, 2-c] thieno [3,
2-e] pyrimidin-3-yl) acetate have been obtained by successive reactions in four stages; …

Exploring the Antiproliferative Potency of Pyrido[2,3‐d]Pyrimidine Derivatives: Studies on Design, Synthesis, Anticancer Evaluation, SAR, Docking, and DFT …

E Abd‐Alsalam, HN Hafez, MG Assay… - Chemistry & …, 2024 - Wiley Online Library
Herein, an efficient method for the synthesis of a new series of pyrido [2, 3‐d] pyrimidine
derivatives has been adopted through the reaction of hydrazinyl pyrido [2, 3‐d] pyrimidine …

Crystal structure, spectroscopic (FT-IR, 1H and 13C NMR) characterization and density functional theory calculations on Ethyl 2-(dichloromethyl)-4-methyl-1-phenyl-6 …

A Pekparlak, Ö Tamer, SD Kanmazalp, N Berber… - Journal of Molecular …, 2018 - Elsevier
A multicomponent reaction between ethyl 3-aminocrotonate, phenyl isothiocyanates, 2, 2-
dichloroacetyl chloride and to give 6-thioxo-1, 6-dihydropyrimidine-5-carboxylate. This one …

Synthesis, structures, spectral properties and DFT quantum chemical calculations of (E)-4-(((4-propylphenyl) imino) methyl) phenol and (E)-4-((2-tolylimino) methyl) …

EE Elemike, HU Nwankwo, DC Onwudiwe… - Journal of Molecular …, 2017 - Elsevier
Two Schiff base compounds with similar backbone, but different positions and lengths of
alkyl groups,(E)-4-(((4-propylphenyl) imino) methyl) phenol (PMP) and (E)-4-((2-tolylimino) …