Mycobacterium tuberculosis (M. tb) is a bacterial pathogen that has evolved in humans, and
its interactions with the host are complex and best studied in humans. Myriad immune …

The absence of validated correlates of protection (CoPs) hampers the rational design and
clinical development of new tuberculosis vaccines. In this review, we provide an overview of …

Interrupting transmission events is critical to tuberculosis control. Cough-generated aerosol
cultures predict tuberculosis transmission better than microbiological or clinical markers. We …

Background Community active case finding (ACF) for tuberculosis was widely implemented
in Europe and North America between 1940 and 1970, when incidence was comparable to …

Pioneering studies linking symptomatic disease and cough-mediated Mycobacterium
tuberculosis (Mtb) release established the infectious origin of tuberculosis (TB) …

Tuberculosis is a leading cause of death from an infectious agent globally. Infectious
subclinical tuberculosis accounts for almost half of all tuberculosis cases in national …

Chronic inflammation triggers development of metabolic disease, and pulmonary
tuberculosis (TB) generates chronic systemic inflammation. Whether TB induced …

The latest data from WHO show that tuberculosis remains a formidable global health
concern, with an estimated 10· 8 million people develo** the disease in 2023 and 1· 25 …

Chronic tuberculosis (TB) disease, which requires months-long chemotherapy with multiple
antibiotics, is defined by diverse pathological manifestations and bacterial phenotypes …

Tuberculosis (TB) is the leading cause of death in the world from an infectious disease. Its
etiologic agent, the Mycobacterium tuberculosis (Mtb), is a slow-growing bacterium that has …