Metabolic engineering: methodologies and applications

MJ Volk, VG Tran, SI Tan, S Mishra, Z Fatma… - Chemical …, 2022 - ACS Publications
Metabolic engineering aims to improve the production of economically valuable molecules
through the genetic manipulation of microbial metabolism. While the discipline is a little over …

Microbial production of advanced biofuels

J Keasling, H Garcia Martin, TS Lee… - Nature Reviews …, 2021 - nature.com
Concerns over climate change have necessitated a rethinking of our transportation
infrastructure. One possible alternative to carbon-polluting fossil fuels is biofuels produced …

Enzyme function prediction using contrastive learning

T Yu, H Cui, JC Li, Y Luo, G Jiang, H Zhao - Science, 2023 - science.org
Enzyme function annotation is a fundamental challenge, and numerous computational tools
have been developed. However, most of these tools cannot accurately predict functional …

Automated in vivo enzyme engineering accelerates biocatalyst optimization

E Orsi, L Schada von Borzyskowski, S Noack… - Nature …, 2024 - nature.com
Achieving cost-competitive bio-based processes requires development of stable and
selective biocatalysts. Their realization through in vitro enzyme characterization and …

Machine learning in enzyme engineering

S Mazurenko, Z Prokop, J Damborsky - ACS catalysis, 2019 - ACS Publications
Enzyme engineering plays a central role in develo** efficient biocatalysts for
biotechnology, biomedicine, and life sciences. Apart from classical rational design and …

Machine learning for metabolic engineering: A review

CE Lawson, JM Martí, T Radivojevic… - Metabolic …, 2021 - Elsevier
Abstract Machine learning provides researchers a unique opportunity to make metabolic
engineering more predictable. In this review, we offer an introduction to this discipline in …

[HTML][HTML] Relieving metabolic burden to improve robustness and bioproduction by industrial microorganisms

J Mao, H Zhang, Y Chen, L Wei, J Liu, J Nielsen… - Biotechnology …, 2024 - Elsevier
Metabolic burden is defined by the influence of genetic manipulation and environmental
perturbations on the distribution of cellular resources. The rewiring of microbial metabolism …

Current status and future prospects in cannabinoid production through in vitro culture and synthetic biology

M Hesami, M Pepe, A Baiton, AMP Jones - Biotechnology Advances, 2023 - Elsevier
For centuries, cannabis has been a rich source of fibrous, pharmaceutical, and recreational
ingredients. Phytocannabinoids are the most important and well-known class of cannabis …

Systems metabolic engineering of microorganisms for food and cosmetics production

KR Choi, SY Lee - Nature Reviews Bioengineering, 2023 - nature.com
The demand for sustainable and environmentally friendly sources of foods and cosmetics is
increasing owing to concerns about the rapid growth of the global population and climate …

Artificial intelligence (AI) applications in adsorption of heavy metals using modified biochar

D Lakshmi, D Akhil, A Kartik, KP Gopinath… - Science of the Total …, 2021 - Elsevier
The process of removal of heavy metals is important due to their toxic effects on living
organisms and undesirable anthropogenic effects. Conventional methods possess many …