Modern human ancestors diverged from the ancestors of Neandertals and Denisovans
about 600,000 years ago. Until about 40,000 years ago, these three groups existed in …

Denisovans, a group of now extinct humans who lived in Eastern Eurasia in the Middle and
Late Pleistocene, were first identified from DNA sequences just over a decade ago. Only ten …

Abstract The Holocene (beginning around 12,000 years ago) encompassed some of the
most significant changes in human evolution, with far-reaching consequences for the …

The extent of the devastation of the Black Death pandemic (1346–1353) on European
populations is known from documentary sources and its bacterial source illuminated by …

Given the many small-effect loci uncovered by genome-wide association studies (GWAS),
polygenic scores have become central to genomic medicine, and have found application in …

Human culture, biology, and health were shaped dramatically by the onset of agriculture∼
12,000 y BP This shift is hypothesized to have resulted in increased individual fitness and …

Ancient DNA provides a powerful window into the biology of extant and extinct species,
including humans' closest relatives: Denisovans and Neanderthals. Here, we review what is …

Signatures of positive selection in the genome are a characteristic mark of adaptation that
can reveal an ongoing, recent, or ancient response to environmental change throughout the …

Objectives Previous research has shown that while missing data are common in
bioarchaeological studies, they are seldom handled using statistically rigorous methods …

Known as a diverse collection of neoplastic diseases, breast cancer (BC) can be
hyperbolically characterized as a dynamic pseudo-organ, a living organism able to build a …