Approved antiviral drugs over the past 50 years
E De Clercq, G Li - Clinical microbiology reviews, 2016 - Am Soc Microbiol
Since the first antiviral drug, idoxuridine, was approved in 1963, 90 antiviral drugs
categorized into 13 functional groups have been formally approved for the treatment of the …
categorized into 13 functional groups have been formally approved for the treatment of the …
RNA dependent RNA polymerases: insights from structure, function and evolution
RNA dependent RNA polymerase (RdRp) is one of the most versatile enzymes of RNA
viruses that is indispensable for replicating the genome as well as for carrying out …
viruses that is indispensable for replicating the genome as well as for carrying out …
Broad-spectrum agents for flaviviral infections: dengue, Zika and beyond
V Boldescu, MAM Behnam, N Vasilakis… - Nature Reviews Drug …, 2017 - nature.com
Infections with flaviviruses, such as dengue, West Nile virus and the recently re-emerging
Zika virus, are an increasing and probably lasting global risk. This Review summarizes and …
Zika virus, are an increasing and probably lasting global risk. This Review summarizes and …
The FDA-approved drug sofosbuvir inhibits Zika virus infection
The rapidly expanding Zika virus (ZIKV) epidemic has affected thousands of individuals with
severe cases causing Guillain-Barré syndrome, congenital malformations, and …
severe cases causing Guillain-Barré syndrome, congenital malformations, and …
Current trends and limitations in dengue antiviral research
JO Obi, H Gutiérrez-Barbosa, JV Chua… - Tropical Medicine and …, 2021 - mdpi.com
Dengue is the most prevalent arthropod-borne viral disease worldwide and affects
approximately 2.5 billion people living in over 100 countries. Increasing geographic …
approximately 2.5 billion people living in over 100 countries. Increasing geographic …
Indole–a promising pharmacophore in recent antiviral drug discovery
A Dorababu - RSC Medicinal Chemistry, 2020 - pubs.rsc.org
The bicyclic molecule indole has been in the limelight because of its numerous
pharmacological potencies. It is used as an excellent scaffold in drug discovery of medicinal …
pharmacological potencies. It is used as an excellent scaffold in drug discovery of medicinal …
A comprehensive study to unleash the putative inhibitors of serotype2 of dengue virus: Insights from an in silico structure-based drug discovery
Dengue fever is a mosquito-borne disease that claims the lives of millions of people around
the world. A number of factors like disease's non-specific symptoms, increased viral …
the world. A number of factors like disease's non-specific symptoms, increased viral …
Potent allosteric dengue virus NS5 polymerase inhibitors: mechanism of action and resistance profiling
SP Lim, CG Noble, CC Seh, TS Soh, A El Sahili… - PLoS …, 2016 - journals.plos.org
Flaviviruses comprise major emerging pathogens such as dengue virus (DENV) or Zika
virus (ZIKV). The flavivirus RNA genome is replicated by the RNA-dependent-RNA …
virus (ZIKV). The flavivirus RNA genome is replicated by the RNA-dependent-RNA …
Zika virus methyltransferase: structure and functions for drug design perspectives
B Coutard, K Barral, J Lichiere, B Selisko… - Journal of …, 2017 - Am Soc Microbiol
ABSTRACT The Flavivirus Zika virus (ZIKV) is the causal agent of neurological disorders like
microcephaly in newborns or Guillain-Barre syndrome. Its NS5 protein embeds a …
microcephaly in newborns or Guillain-Barre syndrome. Its NS5 protein embeds a …
Dengue drug discovery: Progress, challenges and outlook
SP Lim - Antiviral research, 2019 - Elsevier
In the context of the only available vaccine (DENGVAXIA) that was marketed in several
countries, but poses higher risks to unexposed individuals, the development of antivirals for …
countries, but poses higher risks to unexposed individuals, the development of antivirals for …