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Therapeutic strategies for COVID-19: progress and lessons learned
G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
Mucosal immune responses to infection and vaccination in the respiratory tract
The lungs are constantly exposed to inhaled debris, allergens, pollutants, commensal or
pathogenic microorganisms, and respiratory viruses. As a result, innate and adaptive …
pathogenic microorganisms, and respiratory viruses. As a result, innate and adaptive …
[HTML][HTML] SARS-CoV-2-infection-and vaccine-induced antibody responses are long lasting with an initial waning phase followed by a stabilization phase
K Srivastava, JM Carreño, C Gleason, B Monahan… - Immunity, 2024 - cell.com
It is thought that mRNA-based vaccine-induced immunity to severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) wanes quickly, based mostly on short-term studies …
syndrome coronavirus 2 (SARS-CoV-2) wanes quickly, based mostly on short-term studies …
Cepharanthine analogs mining and genomes of Stephania accelerate anti-coronavirus drug discovery
Cepharanthine is a secondary metabolite isolated from Stephania. It has been reported that
it has anti-conronaviruses activities including severe acute respiratory syndrome …
it has anti-conronaviruses activities including severe acute respiratory syndrome …
A pseudovirus system enables deep mutational scanning of the full SARS-CoV-2 spike
A major challenge in understanding SARS-CoV-2 evolution is interpreting the antigenic and
functional effects of emerging mutations in the viral spike protein. Here, we describe a deep …
functional effects of emerging mutations in the viral spike protein. Here, we describe a deep …
[HTML][HTML] Learning from prepandemic data to forecast viral escape
Effective pandemic preparedness relies on anticipating viral mutations that are able to
evade host immune responses to facilitate vaccine and therapeutic design. However, current …
evade host immune responses to facilitate vaccine and therapeutic design. However, current …
Sequential intrahost evolution and onward transmission of SARS-CoV-2 variants
Persistent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections have
been reported in immune-compromised individuals and people undergoing immune …
been reported in immune-compromised individuals and people undergoing immune …
Mucosal vaccines for SARS-CoV-2: scientific gaps and opportunities—workshop report
JM Knisely, LE Buyon, R Mandt, R Farkas… - npj Vaccines, 2023 - nature.com
On November 7th and 8th, 2022, The National Institute of Allergy and Infectious Diseases
(NIAID), part of the National Institutes of Health (NIH), The Coalition for Epidemic …
(NIAID), part of the National Institutes of Health (NIH), The Coalition for Epidemic …
The role of vaccines in the COVID-19 pandemic: what have we learned?
F Krammer - Seminars in Immunopathology, 2024 - Springer
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged late in 2019 and
caused the coronavirus disease 2019 (COVID-19) pandemic that has so far claimed …
caused the coronavirus disease 2019 (COVID-19) pandemic that has so far claimed …
Fitness effects of mutations to SARS-CoV-2 proteins
Abstract Knowledge of the fitness effects of mutations to SARS-CoV-2 can inform
assessment of new variants, design of therapeutics resistant to escape, and understanding …
assessment of new variants, design of therapeutics resistant to escape, and understanding …