Ultra-high-performance liquid chromatography high-resolution mass spectrometry variants for metabolomics research

L Perez de Souza, S Alseekh, F Scossa, AR Fernie - Nature methods, 2021 - nature.com
Ultra-high-performance liquid chromatography high-resolution mass spectrometry (UHPLC–
HRMS) variants currently represent the best tools to tackle the challenges of complexity and …

[HTML][HTML] Cupriavidus necator as a platform for polyhydroxyalkanoate production: an overview of strains, metabolism, and modeling approaches

MS Morlino, RS García, F Savio, G Zampieri… - Biotechnology …, 2023 - Elsevier
Cupriavidus necator is a bacterium with a high phenotypic diversity and versatile metabolic
capabilities. It has been extensively studied as a model hydrogen oxidizer, as well as a …

Real-time bioelectronic sensing of environmental contaminants

JT Atkinson, L Su, X Zhang, GN Bennett, JJ Silberg… - Nature, 2022 - nature.com
Real-time chemical sensing is crucial for applications in environmental and health
monitoring. Biosensors can detect a variety of molecules through genetic circuits that use …

Lipid production in Yarrowia lipolytica is maximized by engineering cytosolic redox metabolism

K Qiao, TM Wasylenko, K Zhou, P Xu… - Nature …, 2017 - nature.com
Microbial factories have been engineered to produce lipids from carbohydrate feedstocks for
production of biofuels and oleochemicals. However, even the best yields obtained to date …

[HTML][HTML] Review of NAD (P) H-dependent oxidoreductases: Properties, engineering and application

LS Vidal, CL Kelly, PM Mordaka, JT Heap - Biochimica et Biophysica Acta …, 2018 - Elsevier
Abstract NAD (P) H-dependent oxidoreductases catalyze the reduction or oxidation of a
substrate coupled to the oxidation or reduction, respectively, of a nicotinamide adenine …

Flavin-Based Electron Bifurcation, Ferredoxin, Flavodoxin, and Anaerobic Respiration With Protons (Ech) or NAD+ (Rnf) as Electron Acceptors: A Historical Review

W Buckel, RK Thauer - Frontiers in microbiology, 2018 - frontiersin.org
Flavin-based electron bifurcation is a newly discovered mechanism, by which a hydride
electron pair from NAD (P) H, coenzyme F420H2, H2, or formate is split by flavoproteins into …

Genetic engineering of microalgae for enhanced lipid production

CF Muñoz, C Südfeld, MIS Naduthodi… - Biotechnology …, 2021 - Elsevier
Microalgae have the potential to become microbial cell factories for lipid production. Their
ability to convert sunlight and CO 2 into valuable lipid compounds has attracted interest from …

A genetically encoded tool to increase cellular NADH/NAD+ ratio in living cells

X Pan, ML Heacock, EN Abdulaziz, S Violante… - Nature chemical …, 2024 - nature.com
Impaired redox metabolism is a key contributor to the etiology of many diseases, including
primary mitochondrial disorders, cancer, neurodegeneration and aging. However …

Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria

C Ubaida-Mohien, A Lyashkov, M Gonzalez-Freire… - Elife, 2019 - elifesciences.org
A decline of skeletal muscle strength with aging is a primary cause of mobility loss and frailty
in older persons, but the molecular mechanisms of such decline are not understood. Here …

[HTML][HTML] Energy conservation via electron bifurcating ferredoxin reduction and proton/Na+ translocating ferredoxin oxidation

W Buckel, RK Thauer - Biochimica et Biophysica Acta (BBA)-Bioenergetics, 2013 - Elsevier
The review describes four flavin-containing cytoplasmatic multienzyme complexes from
anaerobic bacteria and archaea that catalyze the reduction of the low potential ferredoxin by …