Aging is the most prominent risk factor for late-onset Alzheimer's disease. Aging associates
with a chronic inflammatory state both in the periphery and in the central nervous system, the …

A major immunopathological feature of Coronavirus disease-2019 (COVID-19) is excessive
inflammation in the form of “cytokine storm”. The storm is characterized by injurious levels of …

Background Neuroinflammation and microglia play critical roles in the development of
depression. Cluster of differentiation 200 (CD200) is an anti-inflammatory glycoprotein that …

Aging attenuates the overall responsiveness of the immune system to eradicate pathogens.
The increased production of pro-inflammatory cytokines by innate immune cells under basal …

Sex differences are present in brain morphology, sex hormones, aging processes and
immune responses. These differences need to be considered for proper modelling of …

Progress made by the medical community in increasing lifespans comes with the costs of
increasing the incidence and prevalence of age-related diseases, neurodegenerative ones …

Regenerative medicine harnesses the body's innate capacity for self-repair to restore
malfunctioning tissues and organs. Stem cell therapies represent a key regenerative …

The intracellular deposition and intercellular transmission of α-synuclein (α-syn) are shared
pathological characteristics among neurodegenerative disorders collectively known as α …

Cancer and cardiovascular disorders are known as the two main leading causes of mortality
worldwide. Cardiotoxicity is a critical and common adverse effect of cancer-related …

Microglia, as resident macrophages in the central nervous system, play a multifunctional role
in the pathogenesis of Alzheimer's disease (AD). Their clustering around amyloid-β (Aβ) …