NDMA impurity in valsartan and other pharmaceutical products: Analytical methods for the determination of N-nitrosamines

MK Parr, JF Joseph - Journal of Pharmaceutical and Biomedical Analysis, 2019 - Elsevier
Batch recalls for valsartan containing pharmaceutical products in July 2018 initiated a
discussion on possible contaminations with N-nitrosodimethylamine (NDMA). It appeared …

A comprehensive review on various carcinogenic aspects of N-nitrosopiperidine (NPIP)

P Chaudhary, D Singh, P Janmeda - Phytochemistry Reviews, 2024 - Springer
N-nitrosamines, the potential hazardous pollutants, are classified as most mutagenic and
probable carcinogenic compounds. One of the Potentially carcinogenic N-nitroso …

Development of GC-MS/MS Method for Simultaneous Estimation of Four Nitrosoamine Genotoxic Impurities in Valsartan

SR Tummala, KP Amgoth - Turkish Journal of Pharmaceutical …, 2022 - pmc.ncbi.nlm.nih.gov
Objectives: Recently, N-nitrosamines were unexpectedly detected in valsartan and other
generic sartan products. Taking into this account, we developed a sensitive and stable …

Rapid determination of nine N-nitrosamines in dry-cured mackerel (Scomberomorus niphonius) using salting out homogeneous phase extraction with acetonitrile …

H Dong, H Li, M Liang, D Luo, G Liu, X Zeng, W Bai… - Lwt, 2020 - Elsevier
Abstract N-nitrosodimethylamine (NDMA), belonging to N-nitrosamines (NAs), was detected
in several batches of aquatic products in Guangdong, China in 2019, making it urgent to …

Primary evaluation of nine volatile N-nitrosamines in raw red meat from Tian**, China, by HS-SPME-GC–MS

C Sun, R Wang, T Wang, Q Li - Food Chemistry, 2020 - Elsevier
Monitoring of N-nitrosamines in red meats is vital for food safety. The aim of this paper is to
describe the effect of tissue selection, species and seasonal variation on the contents of nine …

Distribution of N-nitrosamines in drinking water and human urinary excretions in high incidence area of esophageal cancer in Huai'an, China

C Zhao, Q Lu, Y Gu, E Pan, Z Sun, H Zhang, J Zhou… - Chemosphere, 2019 - Elsevier
The Huai'an area in Jiangsu Province of East China is an endemic region of esophageal
cancer (EC). The regional heterogeneity of EC suggests that the levels of potential …

Urinary exposure of N-nitrosamines and associated risk of esophageal cancer in a high incidence area in China

C Zhao, J Zhou, Y Gu, E Pan, Z Sun, H Zhang… - Science of the Total …, 2020 - Elsevier
Esophageal cancer (EC) is a deadly malignancy worldwide with a high incidence and
exhibits unevenly geographic prevalence, which suggests that environmental factors are …

Development of a sensitive and stable GC-MS/MS method for simultaneous determination of four N-nitrosamine genotoxic impurities in sartan substances

J Liu, B **e, B Mai, Q Cai, R He, D Guo, Z Zhang… - Journal of analytical …, 2021 - Springer
Recently, N-nitrosamines have been unexpectedly found in generic sartan products. Herein,
we developed a sensitive and stable GC-MS/MS method with multiple reactions monitoring …

Concentration level, health risk assessment and source apportionment of nitrosamines in PM2. 5 in Urumqi during winter time

J Wang, X Zhou, Z Hua, N Jiang, X He - Atmospheric Pollution Research, 2023 - Elsevier
Nitrogen-containing organic compounds (NOCs) in atmospheric particulate matter are
important species for the formation of brown carbon. N-nitrosamines are a class of NOCs …

Determination of atmospheric amines at Seoul, South Korea via gas chromatography/tandem mass spectrometry

NR Choi, JY Lee, YG Ahn, YP Kim - Chemosphere, 2020 - Elsevier
Highlights•Simple and efficient analytical method for atmospheric amines was
established.•The annual mean concentration of the sum of 5 amines was 5.56±2.76 ng/m …