The JAK/STAT signaling pathway: from bench to clinic
X Hu, J Li, M Fu, X Zhao, W Wang - Signal transduction and targeted …, 2021 - nature.com
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …
Biology and regulation of IL-2: from molecular mechanisms to human therapy
IL-2 was first identified as a growth factor capable of driving the expansion of activated
human T cell populations. In the more than 40 years since its discovery, a tremendous …
human T cell populations. In the more than 40 years since its discovery, a tremendous …
An engineered IL-2 partial agonist promotes CD8+ T cell stemness
Adoptive transfer of antigen-specific T cells represents a major advance in cancer
immunotherapy, with robust clinical outcomes in some patients. Both the number of …
immunotherapy, with robust clinical outcomes in some patients. Both the number of …
Strategies to therapeutically modulate cytokine action
WJ Leonard, JX Lin - Nature Reviews Drug Discovery, 2023 - nature.com
Cytokines are secreted or membrane-presented molecules that mediate broad cellular
functions, including development, differentiation, growth and survival. Accordingly, the …
functions, including development, differentiation, growth and survival. Accordingly, the …
The γc family of cytokines: basic biology to therapeutic ramifications
The common cytokine receptor γ chain, γ c, is a component of the receptors for interleukin-2
(IL-2), IL-4, IL-7, IL-9, IL-15, and IL-21. Mutation of the gene encoding γ c results in X-linked …
(IL-2), IL-4, IL-7, IL-9, IL-15, and IL-21. Mutation of the gene encoding γ c results in X-linked …
Immunomodulatory effects of IL-2 and IL-15; implications for cancer immunotherapy
Simple Summary Emerging knowledge of the two type I cytokine family members IL-2 and IL-
15 has led to critical therapeutic implications for cancer treatment. Here we discuss the …
15 has led to critical therapeutic implications for cancer treatment. Here we discuss the …
JAK/STAT cytokine signaling at the crossroad of NK cell development and maturation
Natural Killer (NK) cells are cytotoxic lymphocytes of the innate immune system and play a
critical role in anti-viral and anti-tumor responses. NK cells develop in the bone marrow from …
critical role in anti-viral and anti-tumor responses. NK cells develop in the bone marrow from …
Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8+ T cell stemness and antitumor immunity
D Hermans, S Gautam… - Proceedings of the …, 2020 - National Acad Sciences
Interleukin (IL)-2 and IL-21 dichotomously shape CD8+ T cell differentiation. IL-2 drives
terminal differentiation, generating cells that are poorly effective against tumors, whereas IL …
terminal differentiation, generating cells that are poorly effective against tumors, whereas IL …
Transcription factors associated with IL-15 cytokine signaling during NK cell development
X Wang, XY Zhao - Frontiers in immunology, 2021 - frontiersin.org
Natural killer (NK) cells are lymphocytes primarily involved in innate immunity and possess
important functional properties in anti-viral and anti-tumor responses; thus, these cells have …
important functional properties in anti-viral and anti-tumor responses; thus, these cells have …
Fine-tuning cytokine signals
JX Lin, WJ Leonard - Annual review of immunology, 2019 - annualreviews.org
Cytokines are secreted or otherwise released polypeptide factors that exert autocrine and/or
paracrine actions, with most cytokines acting in the immune and/or hematopoietic system …
paracrine actions, with most cytokines acting in the immune and/or hematopoietic system …