The brain has almost no energy reserve, but its activity coordinates organismal function, a
burden that requires precise coupling between neurotransmission and energy metabolism …

A substantial and diverse body of literature suggests that the pathophysiology of
schizophrenia is related to deficits of bioenergetic function. While antipsychotics are an …

Significance: Our current knowledge of the pathophysiology and molecular mechanisms
causing psychiatric disorders is modest, but genetic susceptibility and environmental factors …

Depression is a mental illness frequently accompanied by disordered energy metabolism. A
dysregulated hypothalamus pituitary adrenal axis response with aberrant glucocorticoids …

Though the pathophysiology of schizophrenia remains poorly understood, altered brain
energy metabolism is increasingly implicated. Here, we conduct meta-analyses of the …

Whereas energy function in the aging brain and their related neurodegenerative diseases
has been explored in some detail, there is limited knowledge about molecular mechanisms …

The levels of the astrocyte markers (GFAP, S100B) were increased unevenly in patients with
schizophrenia. Reactive astrogliosis was found in approximately 70% of patients with …

Epilepsy, intellectual and cortical sensory deficits, and psychiatric manifestations are the
most frequent manifestations of mitochondrial diseases. How mitochondrial dysfunction …

There is growing interest in the ketogenic diet as a treatment for Bipolar Disorder (BD), with
promising anecdotal and small case study reports of efficacy. Yet, the neurobiological …

Converging evidence suggests bioenergetic defects contribute to the pathophysiology of
schizophrenia and may underlie cognitive dysfunction. The transport and metabolism of …