Protein–protein interactions (PPIs) are involved at all levels of cellular organization, thus
making the development of PPI inhibitors extremely valuable. The identification of selective …

Four-membered rings are witnessing significant prominence in medicinal chemistry
discovery programs. For example, a search of the chemical databases shows exponential …

The most recent papers describing the stereoselective synthesis of cyclic quaternary α-
amino acids are collected in this review. The diverse synthetic approaches are classified …

Lactams are a class of compounds important for drug design, due to their great variety of
potential therapeutic applications, spanning cancer, diabetes, and infectious diseases. So …

Concise asymmetric total syntheses of the fungal metabolites (−)-stephacidin A,(+)-
stephacidin B, and (+)-notoamide B are described. Key features of these total syntheses …

Background N-methyl-D-aspartate receptors are one member of a family of ionotropic
glutamate receptors that play a pivotal role in synaptic plasticity processes associated with …

The synthesis and antimicrobial activity of new spiro-β-lactams is reported. The design of the
new molecules was based on the structural modulation of two previously identified lead …

A novel collection of tripodal β-lactam derivatives with 1, 3, 5-triazine as the central core is
presented for the first time. The diastereoselective synthesis of tris-β-lactams was achieved …

Spirocycles represent an emerging class of privileged motifs for drug discovery. The
versatility of diazo compounds in constructing cyclic frameworks in general makes cyclic …

Synthesis of the tetracyclic core skeleton of the lundurines by a gold-catalyzed cyclization -
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