While a sizable body of research demonstrates the associations between social connection
and health, much of the recent focus in the broader public and to some extent among …

Prolonged periods of social isolation can have detrimental effects on the physiology and
behavior of exposed individuals in humans and animal models. This involves complex …

Stroke remains a leading cause of disability in the United States. Despite recent advances,
interventions to reduce damage and enhance recovery after stroke are lacking. P2X4R, a …

The biology underlying the connection between social relationships and health is largely
unknown. Here, leveraging data from 42,062 participants across 2,920 plasma proteins in …

Introduction Acute ischemic injury leads to severe neuronal loss. One of the key
mechanisms responsible for this effect is inflammation, which is characterized by the …

Elderly stroke patients and aged animals subjected to experimental stroke have significantly
worse functional recovery and higher mortality compared to younger subjects. Activation of …

Normal aging is accompanied by hippocampus-dependent cognitive impairment, which is a
risk factor of Alzheimer's disease. This study aims to investigate the effect of high frequency …

Social isolation (ISO) is associated with an increased risk and poor outcomes of ischemic
stroke. However, the roles and mechanisms of ISO in stroke-associated pneumonia (SAP) …

The microbiome influences the emotional and cognitive phenotype of its host, as well as the
neurodevelopment and pathophysiology of various brain processes and disorders, via the …

Ischemic brain injury is a serious neurological complication, which accrues an immense
activation of neuroinflammatory responses. Several lines of research suggested the …