For decades, disintegrin and metalloproteinase 17 (ADAM17) has been the object of deep
investigation. Since its discovery as the tumor necrosis factor convertase, it has been …

Proteolytic cleavage of transmembrane proteins is an important post-translational
modification that regulates the biological function of numerous transmembrane proteins …

The protease A Disintegrin And Metalloproteinase 17 (ADAM17) plays a central role in the
pathophysiology of several diseases. ADAM17 is involved in the cleavage and shedding of …

A disintegrin and metalloprotease 17 (ADAM17) is a membrane-tethered protease that
triggers multiple signaling pathways. It releases active forms of the primary inflammatory …

All ligands of the epidermal growth factor receptor (EGF-R) are transmembrane proteins,
which need to be proteolytically cleaved in order to be systemically active. The major …

iRhom proteins are catalytically inactive relatives of rhomboid intramembrane proteases.
There is a rapidly growing body of evidence that these pseudoenzymes have a central …

Disintegrin and metalloproteinases (ADAMs) 10 and 17 can release the extracellular part of
a variety of membrane-bound proteins via ectodomain shedding important for many …

Several membrane-bound proteins with a single transmembrane domain are subjected to
limited proteolysis at the cell surface. This cleavage leads to the release of their biologically …

A disintegrin and metalloproteases (ADAMs) are key mediators of cell signaling by
ectodomain shedding of various growth factors, cytokines, receptors and adhesion …

The present study was aimed at evaluating the quality of life in the districts of Buraidah city in
the Kingdom of Saudi Arabia as part of the Kingdom's Vision 2030, based on provided …