Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications
Ferroptosis, a form of cell death driven by iron-dependent lipid peroxidation, was identified
as a distinct phenomenon and named a decade ago. Ferroptosis has been implicated in a …
as a distinct phenomenon and named a decade ago. Ferroptosis has been implicated in a …
[HTML][HTML] Ferroptosis at the intersection of lipid metabolism and cellular signaling
Ferroptosis, a newly emerged form of regulated necrotic cell death, has been demonstrated
to play an important role in multiple diseases including cancer, neurodegeneration, and …
to play an important role in multiple diseases including cancer, neurodegeneration, and …
Ferroptosis: molecular mechanisms and health implications
Cell death can be executed through different subroutines. Since the description of
ferroptosis as an iron-dependent form of non-apoptotic cell death in 2012, there has been …
ferroptosis as an iron-dependent form of non-apoptotic cell death in 2012, there has been …
Ferroptosis: machinery and regulation
Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death caused by lipid
peroxidation, which is controlled by integrated oxidation and antioxidant systems. The iron …
peroxidation, which is controlled by integrated oxidation and antioxidant systems. The iron …
Iron metabolism in ferroptosis
Ferroptosis is a form of regulated cell death that is characterized by iron-dependent
oxidative damage and subsequent plasma membrane ruptures and the release of damage …
oxidative damage and subsequent plasma membrane ruptures and the release of damage …
Signaling pathways and defense mechanisms of ferroptosis
As a type of lytic cell death driven by unrestricted lipid peroxidation and subsequent plasma
membrane damage, ferroptosis occurs and develops because of sophisticated signals and …
membrane damage, ferroptosis occurs and develops because of sophisticated signals and …
System Xc −/GSH/GPX4 axis: An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy
FJ Li, HZ Long, ZW Zhou, HY Luo, SG Xu… - Frontiers in …, 2022 - frontiersin.org
The activation of ferroptosis is a new effective way to treat drug-resistant solid tumors.
Ferroptosis is an iron-mediated form of cell death caused by the accumulation of lipid …
Ferroptosis is an iron-mediated form of cell death caused by the accumulation of lipid …
Ferroptosis, radiotherapy, and combination therapeutic strategies
Ferroptosis, an iron-dependent form of regulated cell death driven by peroxidative damages
of polyunsaturated-fatty-acid-containing phospholipids in cellular membranes, has recently …
of polyunsaturated-fatty-acid-containing phospholipids in cellular membranes, has recently …
Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11
A challenge in oncology is to rationally and effectively integrate immunotherapy with
traditional modalities, including radiotherapy. Here, we demonstrate that radiotherapy …
traditional modalities, including radiotherapy. Here, we demonstrate that radiotherapy …
[HTML][HTML] Ferroptosis is critical for phthalates driving the blood-testis barrier dysfunction via targeting transferrin receptor
Y Zhao, H Zhang, JG Cui, JX Wang, MS Chen… - Redox Biology, 2023 - Elsevier
The global rate of human male infertility is rising at an alarming rate owing to environmental
and lifestyle changes. Phthalates are the most hazardous chemical additives in plastics and …
and lifestyle changes. Phthalates are the most hazardous chemical additives in plastics and …