Endotheliopathy in acute COVID-19 and long COVID

AG Vassiliou, CS Vrettou, C Keskinidou… - International Journal of …, 2023 - mdpi.com
The pulmonary endothelium is a highly regulated organ that performs a wide range of
functions under physiological and pathological conditions. Since endothelial dysfunction …

Renin-angiotensin system and sex differences in COVID-19: a critical assessment

MC Chappell - Circulation Research, 2023 - ahajournals.org
The current epidemic of corona virus disease (COVID-19) has resulted in an immense
health burden that became the third leading cause of death and potentially contributed to a …

[HTML][HTML] Circulating ACE2 activity predicts mortality and disease severity in hospitalized COVID-19 patients

M Fagyas, Z Fejes, R Sütő, Z Nagy, B Székely… - International Journal of …, 2022 - Elsevier
Objectives Angiotensin-converting enzyme 2 (ACE2) represents the primary receptor for
SARS-CoV-2 to enter endothelial cells. Here we investigated circulating ACE2 activity to …

Plasma ACE2 predicts outcome of COVID-19 in hospitalized patients

TW Kragstrup, HS Singh, I Grundberg, ALL Nielsen… - PloS one, 2021 - journals.plos.org
Aims Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to angiotensin
converting enzyme 2 (ACE2) enabling entrance of the virus into cells and causing the …

Low vitamin D levels predict outcomes of COVID-19 in patients with both severe and non-severe disease at hospitalization

L Di Filippo, M Uygur, M Locatelli, F Nannipieri, S Frara… - Endocrine, 2023 - Springer
Purpose Low vitamin D in COVID-19 have been related to worse outcomes. However, most
of the studies conducted so far were not-controlled and retrospective, including biases …

An ACE2 decoy can be administered by inhalation and potently targets omicron variants of SARS‐CoV‐2

L Zhang, KK Narayanan, L Cooper… - EMBO molecular …, 2022 - embopress.org
Monoclonal antibodies targeting the SARS‐CoV‐2 spike (S) neutralize infection and are
efficacious for the treatment of COVID‐19. However, SARS‐CoV‐2 variants, notably …

ACE2 Shedding and the Role in COVID-19

J Wang, H Zhao, Y An - Frontiers in Cellular and Infection …, 2022 - frontiersin.org
Angiotensin converting enzyme 2 (ACE2), a transmembrane glycoprotein, is an important
part of the renin-angiotensin system (RAS). In the COVID-19 epidemic, it was found to be the …

S protein, ACE2 and host cell proteases in SARS-CoV-2 cell entry and infectivity; is soluble ACE2 a two blade sword? A narrative review

R Nejat, MF Torshizi, DJ Najafi - Vaccines, 2023 - mdpi.com
Since the spread of the deadly virus SARS-CoV-2 in late 2019, researchers have restlessly
sought to unravel how the virus enters the host cells. Some proteins on each side of the …

[HTML][HTML] Inflammatory biomarkers to predict the prognosis of acute bacterial and viral infections

AH de Nooijer, P Pickkers, MG Netea, M Kox - Journal of Critical Care, 2023 - Elsevier
Mortality in acute infections is mostly associated with sepsis, defined as 'life-threatening
organ dysfunction caused by a dysregulated host response to infection'. It remains …

Angiotensin-Converting Enzyme (ACE) level, but not ACE gene polymorphism, is associated with prognosis of COVID-19 infection: Implications for diabetes and …

O Elbasan, F Bayram, CD Yazan, T Apaydın… - PloS one, 2023 - journals.plos.org
Background The renin-angiotensin-aldosterone system was shown to be activated in severe
COVID-19 infection. We aimed to investigate the relationship between angiotensin …