ATP-binding cassette (ABC) proteins were first recognized for their role in multidrug
resistance (MDR) in chemotherapeutic treatments, which is a major impediment for the …

In this study we examined gene expression of a series of ABC efflux transporters in various
rainbow trout (Oncorhynchus mykiss) tissues. Based on their reported toxicological …

The aim of this study was to evaluate the response of ABC transporters, CYP1A and class
alpha (α) GST genes, upon water and dietary exposures to benzo (a) pyrene (BaP) in …

ABCC1/MRP1 belongs to the ATP-binding cassette superfamily and its elevated expression
is closely associated with the multidrug resistance of various tumor cells. In normal tissues …

Cellular defence against accumulation of toxic xenobiotics includes metabolism by phase I
and II enzymes and export of toxicants and their metabolites via ATP-binding cassette (ABC) …

Prediction of xenobiotic fate in fish is important for the regulatory assessment of chemicals
under current legislation. Trout hepatocyte spheroids are a promising in vitro model for this …

Xenobiotic transport proteins are involved in cellular defence against accumulation of
xenobiotics participating in multixenobiotic resistance (MXR). In order to study the …

Embryos of oviparous fish, in contrast to (ovo) viviparous species, develop in the aquatic
environment, and therefore need solute transport systems at their body surfaces for …

Pentachlorophenol (PCP) is a typical toxicant and prevailing pollutant whose toxicity has
been broadly investigated. However, previous studies did not specifically investigate the …

The multi-xenobiotics resistance (MXR) mechanisms are the first line of defense against
toxic substances in aquatic organisms and present great importance in the adaptation …