Ferroptosis is a non-apoptotic cell death mechanism characterized by iron-dependent
membrane lipid peroxidation. Here, we review what is known about the cellular mechanisms …

Rampant phospholipid peroxidation initiated by iron causes ferroptosis unless this is
restrained by cellular defences. Ferroptosis is increasingly implicated in a host of diseases …

Palbociclib is a CDK4/6 inhibitor approved for the treatment of breast cancer by suppressing
cell proliferation. However, monotherapy with palbociclib was discouraging in prostate …

CDK4/6 inhibition in combination with endocrine therapy is the standard of care for estrogen
receptor (ER+) breast cancer, and although cytostasis is frequently observed, new treatment …

Elevated lipid metabolism is one of hallmarks of malignant tumors. Lipids not only serve as
essential structural components of biological membranes but also provide energy and …

Drug resistance is the leading cause of treatment failure in patients with cancer. Thus,
innovative therapeutic strategies are required to overcome this critical challenge and …

Five acyl-CoA synthetase long-chain family members (ACSLs) are responsible for catalyzing
diverse long-chain fatty acids (LCFAs) into LCFA-acyl-coenzyme A (CoA) for their …

Metastatic dissemination to distant organs demands that cancer cells possess high
morphological and metabolic adaptability. However, contributions of the cellular lipidome to …

Ferroptosis, an iron-dependent form of regulated cell death, is emerging as a crucial
regulator of human physiology and pathology. Increasing evidence showcases a reciprocal …

Peroxiredoxin 6 (PRDX6) is a multifunctional enzyme involved in phospholipid peroxide
repair and metabolism. In this study we investigated the global lipid composition of a human …