Pathogenic mechanisms following ischemic stroke

SE Khoshnam, W Winlow, M Farzaneh, Y Farbood… - Neurological …, 2017 - Springer
Stroke is the second most common cause of death and the leading cause of disability
worldwide. Brain injury following stroke results from a complex series of pathophysiological …

[HTML][HTML] Ischemia-reperfusion injury in the brain: mechanisms and potential therapeutic strategies

L Lin, X Wang, Z Yu - Biochemistry & pharmacology: open access, 2016 - ncbi.nlm.nih.gov
Ischemia-reperfusion injury is a common feature of ischemic stroke, which occurs when
blood supply is restored after a period of ischemia. Reperfusion can be achieved either by …

Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use

U Dirnagl, K Becker, A Meisel - The Lancet Neurology, 2009 - thelancet.com
Neuroprotection and brain repair in patients after acute brain damage are still major
unfulfilled medical needs. Pharmacological treatments are either ineffective or confounded …

Postconditioning and protection from reperfusion injury: where do we stand? Position paper from the Working Group of Cellular Biology of the Heart of the European …

M Ovize, GF Baxter, F Di Lisa… - Cardiovascular …, 2010 - academic.oup.com
Ischaemic postconditioning (brief periods of ischaemia alternating with brief periods of
reflow applied at the onset of reperfusion following sustained ischaemia) effectively reduces …

Methods, devices, and systems for postconditioning with clot removal

A Turjman, J Bernstein - US Patent 9,445,828, 2016 - Google Patents
(57) New devices, systems, and methods are disclosed for pre venting, treating, and/or at
least minimizing ischemia and/or reperfusion injury by restoring and/or modulating blood …

Neuroprotective effect of Danhong injection on cerebral ischemia-reperfusion injury in rats by activation of the PI3K-Akt pathway

C Feng, H Wan, Y Zhang, L Yu, C Shao, Y He… - Frontiers in …, 2020 - frontiersin.org
Many traditional Chinese medicines, including Danhong injection (DHI), can be used to treat
cerebral ischemia-reperfusion injury and have neuroprotective effects on the brain; however …

Limb remote ischemic postconditioning protects against focal ischemia in rats

C Ren, Z Yan, D Wei, X Gao, X Chen, H Zhao - Brain research, 2009 - Elsevier
Remote ischemic postconditioning (RIP) refers to an ischemia conducted in a distant organ
that protects against a prior ischemia in another organ. We tested whether RIP protects …

Sirtuin 6 protects the brain from cerebral ischemia/reperfusion injury through NRF2 activation

W Zhang, R Wei, L Zhang, Y Tan, C Qian - Neuroscience, 2017 - Elsevier
Abstract Sirtuin 6 (SIRT6), a member of the sirtuin family of NAD (+)-dependent
deacetylases, has been shown to produce beneficial effects in myocardial …

Ischemic postconditioning as a novel avenue to protect against brain injury after stroke

H Zhao - Journal of Cerebral Blood Flow & Metabolism, 2009 - journals.sagepub.com
Ischemic postconditioning initially referred to a stuttering reperfusion performed immediately
after reperfusion, for preventing ischemia/reperfusion injury in both myocardial and cerebral …

Postconditioning with isoflurane reduced ischemia-induced brain injury in rats

JJ Lee, L Li, HH Jung, Z Zuo - Anesthesiology, 2008 - pmc.ncbi.nlm.nih.gov
Background: Pre-exposure of brain to isoflurane, a commonly used anesthetic, induces
ischemic tolerance. This phenomenon is called isoflurane preconditioning. However, it is not …