The use of arylboron reagents in metal‐catalyzed domino addition–cyclization reactions is a
well‐established strategy for the preparation of diverse, highly functionalized carbo‐and …

Because of the critical roles of aberrant signaling in cancer, both c-MET and ALK receptor
tyrosine kinases are attractive oncology targets for therapeutic intervention. The cocrystal …

The introduction of fluorine‐containing groups into organic molecules can significantly affect
their physical and chemical properties and has long been used as an effective strategy for …

Focal adhesion tyrosine kinase (PTK2) is often overexpressed in human hepatocellular
carcinoma (HCC), and several reports have linked PTK2 depletion and/or pharmacological …

Direct synthesis of N-heterocycles via the acceptorless dehydrogenative coupling is very
challenging and scarcely reported under 3d transition-metal catalysis. Here, we have …

Achieving complex molecular assemblies in modular modes is always one of the top
priorities of the organic chemist. Cyclization/annulation of functionalized alkynes through …

The recently developed artificial force induced reaction (AFIR) method was applied to
search systematically all possible multicomponent pathways for the Biginelli reaction …

The development of synthetic methods to produce highly functionalized chiral 3‐pyrrolines is
of indisputable importance because of their prevalence in natural and synthetic bioactive …

Fungal genome projects are revealing thousands of cryptic secondary metabolism (SM)
biosynthetic gene clusters that encode pathways that potentially produce valuable …

An efficient, atom-economical, and regioselective insertion of indoles into terminal alkynes
has been realized via cobalt (III)-catalyzed C–H activation under mild conditions, leading to …