One of the biggest challenges in managing multiple sclerosis is the heterogeneity of clinical
manifestations and progression trajectories. It still remains to be elucidated whether this …

Neuroinflammation is a pathophysiological hallmark of multiple sclerosis and has a close
mechanistic link to neurodegeneration. Although this link is potentially targetable, robust …

Inflammatory demyelination characterizes the initial stages of multiple sclerosis, while
progressive axonal and neuronal loss are coexisting and significantly contribute to the long …

Disability in multiple sclerosis is generally classified by sensory and motor symptoms, yet
cognitive impairment has been identified as a frequent manifestation already in the early …

The identification of prognostic markers in early multiple sclerosis (MS) is challenging and
requires reliable measures that robustly predict future disease trajectories. Ideally, such …

Despite the clinical significance of narcissistic personality, its neural bases have not been
clarified yet, primarily because of methodological limitations of the previous studies, such as …

The link between white matter hyperintensities (WMH) and cortical thinning is thought to be
an important pathway by which WMH contributes to cognitive deficits in cerebral small …

Background and Objectives Immunomodulatory therapies reduce the relapse rate but only
marginally control disability progression in patients with MS. Although serum neurofilament …

Multiple sclerosis (MS) is an autoimmune disease of the brain and spinal cord with both
inflammatory and neurodegenerative features. Although advances in imaging techniques …

Patients afflicted by multiple sclerosis experience a relapsing-remitting course in about 85%
of the cases. Furthermore, after a 10/15-year period their situation tends to worse, resulting …