Osteoarthritis is the most common joint disorder with increasing prevalence due to aging of
the population. Its multi-factorial etiology includes oxidative stress and the overproduction of …

The perception of nociceptive signals, which are translated into pain, plays a fundamental
role in the survival of organisms. Because pain is linked to a negative sensation, animals …

Metal ions play important roles in biological processes, 1 and the field of knowledge
concerned with the application of inorganic chemistry to therapy or diagnosis of disease is …

Osteoarthritis (OA) is a whole joint disease driven by abnormal biomechanics and attendant
cell-derived and tissue-derived factors. The disease is multifactorial and polygenic, and its …

The objective of the present study was to evaluate the antinociceptive effects of phytol using
chemical and thermal models of nociception in mice and to assess its antioxidant effects in …

Peroxynitrite—the product of the diffusion-controlled reaction of nitric oxide with superoxide
radical—is a short-lived oxidant species that is a potent inducer of cell death. Conditions in …

Oxidative stress has become widely viewed as an underlying condition in a number of
diseases, such as ischemia–reperfusion disorders, central nervous system disorders …

Studies have shown that diterpenes have anti‐inflammatory and redox‐protective
pharmacological activities. The present study aimed to investigate the anti‐inflammatory …

Vanillic acid (1) is a flavoring agent found in edible plants and fruits. It is an oxidized form of
vanillin. Phenolic compounds form a substantial part of plant foods used as antioxidants with …

Peroxynitrite (PN; ONOO−) and its reactive oxygen precursor superoxide (SO; O2•−) are
critically important in the development of pain of several etiologies including pain associated …