Cell secretome strategies for controlled drug delivery and wound-healing applications

R Ibrahim, H Mndlovu, P Kumar, SA Adeyemi… - Polymers, 2022 - mdpi.com
There is significant interest in using stem cells in the management of cutaneous wounds.
However, potential safety, efficacy, and cost problems associated with whole-cell …

Microneedle-Mediated Transdermal Delivery of Genetic Materials, Stem Cells, and Secretome: An Update and Progression

ADC Nainggolan, QK Anjani, P Hartrianti, RF Donnelly… - Pharmaceutics, 2023 - mdpi.com
Medical practitioners commonly use oral and parenteral dosage forms to administer drugs to
patients. However, these forms have certain drawbacks, particularly concerning patients' …

Double-layer dissolving microneedles for delivery of mesenchymal stem cell Secretome: Formulation, characterisation and skin irritation study

ADC Nainggolan, P Hartrianti, QK Anjani… - European Journal of …, 2024 - Elsevier
Regenerative therapy based on stem cells have been developed, focusing on either stem
cell or secretome delivery. Most marketed cellular and gene therapy products are available …

Mesenchymal Stem Cell Secretome: A Potential Biopharmaceutical Component to Regenerative Medicine?

B Araújo, RC Silva, S Domingues, AJ Salgado… - Handbook of Stem Cell …, 2022 - Springer
Over the last decade, the use of stem cells has remarkably been proposed as a regenerative
tool, and within it, mesenchymal stem cells (MSCs) have emerged as a promising …

Mesenchymal Stem Cells Therapeutic Applications in Central Nervous System Disorders

MB Gugjoo - Therapeutic Applications of Mesenchymal Stem Cells …, 2022 - Springer
Mammalian nervous system is the most complex and little understood system of the body.
An ailment to any structure of the central nervous system often leads to the mal-or non …

Interplay Between Adipose-Derived Stem Cells and Inflammatory Mediators: Impact on Neurite Outgrowth and Vascular Morphogenesis

JVL Afonso - 2021 - search.proquest.com
A lesão da medula espinal (SCI) é uma condição que impede a comunicação entre o
cérebro eo resto do corpo, resultando em comorbidades que diminuem a qualidade de vida …

Development of Secretome-Based Therapy by Motor Neuron Modulation of miRNA-124 in ALS Mouse Models

HMM Morais - 2020 - search.proquest.com
Abstract Amyotrophic Lateral Sclerosis (ALS) is a fatal disease characterized by the
degeneration of upper (cortical) and lower (spinal cord, SC) motor neurons (MNs) and …