Stem cells play an important role in restoring cardiac function in the damaged heart. In order
to mediate repair, stem cells need to replace injured tissue by differentiating into specialized …

The global impetus to identify curative therapies has been fuelled by the unmet needs of
patients in the context of a growing heart failure pandemic. To date, regeneration trials in …

Background Pilot trials suggest that the intracoronary administration of autologous
progenitor cells may improve left ventricular function after acute myocardial infarction …

Background The benefit of reperfusion therapies for ST-elevation acute myocardial infarction
(STEMI) is limited by post-infarction left-ventricular (LV) dysfunction. Our aim was to …

Background Previous studies have shown improvement in left ventricular function after
intracoronary injection of autologous cells derived from bone marrow (BMC) in the acute …

Background—Intracoronary transfer of autologous bone marrow cells (BMCs) may enhance
recovery of left ventricular (LV) function in patients after acute myocardial infarction (AMI) …

Background—Cardiosphere-derived cells (CDCs) isolated from human endomyocardial
biopsies reduce infarct size and improve cardiac function in mice. Safety and efficacy testing …

Aims To provide systematic assessment of the safety and efficacy of autologous bone
marrow-derived stem cell (BMSC) transplantation in acute myocardial infarction (AMI) based …

Introduction Ischemic heart diseases, especially the myocardial infarction, is a major hazard
problem to human health. Despite substantial advances in control of risk factors and …

Background—Relevant preclinical models are necessary for further mechanistic and
translational studies of c-kit+ cardiac stem cells (CSCs). The present study was undertaken …