The development and clinical application of innovative optical ophthalmic imaging techniques

P Alexopoulos, C Madu, G Wollstein… - Frontiers in …, 2022 - frontiersin.org
The field of ophthalmic imaging has grown substantially over the last years. Massive
improvements in image processing and computer hardware have allowed the emergence of …

Light-scattering methods for tissue diagnosis

ZA Steelman, DS Ho, KK Chu, A Wax - Optica, 2019 - opg.optica.org
Light scattering has become a common biomedical research tool, enabling diagnostic
sensitivity to myriad tissue alterations associated with disease. Light–tissue interactions are …

Diverse research teams and underrepresented groups in clinical studies

A Bains, P Osathanugrah, N Sanjiv, C Chiu… - JAMA …, 2023 - jamanetwork.com
Importance Several ophthalmic diseases disproportionately affect racial and ethnic minority
patients, yet most clinical trials struggle to enroll cohorts that are demographically …

Visible light optical coherence tomography angiography (vis-OCTA) facilitates local microvascular oximetry in the human retina

W Song, W Shao, W Yi, R Liu, M Desai… - Biomedical Optics …, 2020 - opg.optica.org
We report herein the first visible light optical coherence tomography angiography (vis-OCTA)
for human retinal imaging. Compared to the existing vis-OCT systems, we devised a …

Global and regional damages in retinal ganglion cell axon bundles monitored non-invasively by visible-light optical coherence tomography fibergraphy

M Grannonico, DA Miller, M Liu, P Norat… - Journal of …, 2021 - Soc Neuroscience
Retinal ganglion cells (RGCs) exhibit compartmentalized organization, receiving synaptic
inputs through their dendrites and transmitting visual information from the retina to the brain …

In vivo Morphometry of Inner Plexiform Layer (IPL) Stratification in the Human Retina With Visible Light Optical Coherence Tomography

T Zhang, AM Kho, VJ Srinivasan - Frontiers in Cellular Neuroscience, 2021 - frontiersin.org
From the bipolar cells to higher brain visual centers, signals in the vertebrate visual system
are transmitted along parallel on and off pathways. These two pathways are spatially …

Simultaneous visible light optical coherence tomography and near infrared OCT angiography in retinal pathologies: a case study

J Wang, A Baker, ML Subramanian… - Experimental …, 2022 - journals.sagepub.com
A dual-channel optical coherence tomography system with wavelengths in the visible and
near-infrared light ranges can provide both structural and functional information for retinal …

A Generic and Effective System Dispersion Compensation Method: Development and Validation in Visible-Light OCT

J Wang, C Xu, S Zhu, D Chen, H Qiu, AKN Lam… - Photonics, 2023 - mdpi.com
Compared with optical coherence tomography (OCT) in the near-infrared domain, the visible-
light OCT (vis-OCT) system affords a higher axial resolution for discerning subtle …

Light-weight Retinal Layer Segmentation with Global Reasoning

X He, W Song, Y Wang, F Poiesi, J Yi… - IEEE Transactions …, 2024 - ieeexplore.ieee.org
Automatic retinal layer segmentation with medical images, such as optical coherence
tomography (OCT) images, serves as an important tool for diagnosing ophthalmic diseases …

Hyperspectral optical coherence tomography for in vivo visualization of melanin in the retinal pigment epithelium

DJ Harper, T Konegger, M Augustin… - Journal of …, 2019 - Wiley Online Library
Previous studies for melanin visualization in the retinal pigment epithelium (RPE) have
exploited either its absorption properties (using photoacoustic tomography or photothermal …