Targeting the “hallmarks of aging” to slow aging and treat age-related disease: fact or fiction?

M Keshavarz, K **e, K Schaaf, D Bano… - Molecular …, 2023 - nature.com
Aging is a major risk factor for a number of chronic diseases, including neurodegenerative
and cerebrovascular disorders. Aging processes have therefore been discussed as potential …

The growth hormone receptor: mechanism of receptor activation, cell signaling, and physiological aspects

F Dehkhoda, CMM Lee, J Medina… - Frontiers in …, 2018 - frontiersin.org
The growth hormone receptor (GHR), although most well known for regulating growth, has
many other important biological functions including regulating metabolism and controlling …

The GH/IGF-1 axis in ageing and longevity

RK Junnila, EO List, DE Berryman, JW Murrey… - Nature Reviews …, 2013 - nature.com
Secretion of growth hormone (GH), and consequently that of insulin-like growth factor 1 (IGF-
1), declines over time until only low levels can be detected in individuals aged≥ 60 years …

Targeting growth hormone function: strategies and therapeutic applications

M Lu, JU Flanagan, RJ Langley, MP Hay… - Signal transduction and …, 2019 - nature.com
Human growth hormone (GH) is a classical pituitary endocrine hormone that is essential for
normal postnatal growth and has pleiotropic effects across multiple physiological systems …

Serum biomarker panels for the diagnosis of gastric cancer

D Wu, P Zhang, J Ma, J Xu, L Yang, W Xu… - Cancer …, 2019 - Wiley Online Library
Gastric cancer is a leading cause of mortality due to neoplastic disease. Although early
detection of gastric cancers can decrease the mortality rate, it remains a diagnostic …

Growth hormone and reproduction: a review of endocrine and autocrine/paracrine interactions

KL Hull, S Harvey - International journal of endocrinology, 2014 - Wiley Online Library
The somatotropic axis, consisting of growth hormone (GH), hepatic insulin‐like growth factor
I (IGF‐I), and assorted releasing factors, regulates growth and body composition …

JAK2 activation by growth hormone and other cytokines

MJ Waters, AJ Brooks - Biochemical Journal, 2015 - portlandpress.com
Growth hormone (GH) and structurally related cytokines regulate a great number of
physiological and pathological processes. They do this by coupling their single …

Non-pituitary GH regulation of the tissue microenvironment

V Chesnokova, S Melmed - Endocrine-related cancer, 2023 - erc.bioscientifica.com
Non-pituitary growth hormone (npGH) expression is well established in extrapituitary
tissues, but an understanding of the physiological role of npGH remains rather limited. Pro …

Autocrine/paracrine human growth hormone-stimulated MicroRNA 96-182-183 cluster promotes epithelial-mesenchymal transition and invasion in breast cancer

W Zhang, P Qian, X Zhang, M Zhang, H Wang… - Journal of Biological …, 2015 - ASBMB
Human growth hormone (hGH) plays critical roles in pubertal mammary gland growth,
development, and sexual maturation. Accumulated studies have reported that …

Growth hormone treatment for childhood short stature and risk of stroke in early adulthood

A Poidvin, E Touze, E Ecosse, F Landier, Y Bejot… - Neurology, 2014 - AAN Enterprises
Objectives: We investigated the incidence of stroke and stroke subtypes in a population-
based cohort of patients in France treated with growth hormone (GH) for short stature in …