Regulation of intracellular calcium is a critical component of cardiac electrophysiology and
excitation-contraction coupling. The calcium spark, the fundamental element of the …

Ventricular arrhythmias are the primary cause of sudden cardiac death and one of the
leading causes of mortality worldwide. Whole-heart computational modeling offers a unique …

In the chronic stage of myocardial infarction, a significant number of patients develop life-
threatening ventricular tachycardias (VT) due to the arrhythmogenic nature of the remodeled …

Fibrosis has been mechanistically linked to arrhythmogenesis in multiple cardiovascular
conditions, including atrial fibrillation (AF). Previous studies have demonstrated that fibrosis …

The development of effective and safe therapies for scar-related ventricular tachycardias
requires a detailed understanding of the mechanisms underlying the conduction block that …

Background: Atrial fibrillation (AF), the most common cardiac arrhythmia, is characterized by
alteration of the action potential (AP) propagation. Under persistent AF, myocytes undergo …

Customization of mathematical and numerical models to patient-specific settings is a critical
step of the translation process bringing scientific computing to the clinical activity. In …

Initiation of reentry requires 2 factors:(1) a triggering event, most commonly focal excitations
such as premature ventricular complexes (PVCs); and (2) a vulnerable substrate with …

Ectopic beats are known to be involved in the initiation of a variety of cardiac arrhythmias.
Although their location may vary, ectopic excitations have been found to originate from …

Spontaneous sub-cellular calcium release events (SCRE) are conjectured to promote rapid
arrhythmias associated with conditions such as heart failure and atrial fibrillation: they can …