Upregulation of sialyltransferases—the enzymes responsible for the addition of sialic acid to
growing glycoconjugate chains—and the resultant hypersialylation of up to 40–60% of …

The substitution of primary or secondary alcohols with nucleophiles mediated by a redox
combination of a trialkylor triarylphosphine and a dialkyl azodicarboxylate is popularly …

Metastasis accounts for the majority of cancer-associated mortalities, representing a huge
health and economic burden. One of the mechanisms that enables metastasis is …

Mucin-type O-linked glycosylation is a fundamental post-translational modification that is
involved in a variety of important biological processes. However, the lack of chemical tools to …

1. Introduction a-Aminoalkylphosphonic acids 1 are structurally analogous to a-amino acids
2, obtained by isosteric substitution of the planar and less bulky carboxylic acid (CO2H) by a …

Hydroxyphosphonates have attracted considerable attention as biologically active
compounds, enzyme inhibitors, and drugs. Over the last few years significant interest in the …

Zirconium (IV) compounds are reported as excellent catalysts for a three-component one-pot
reaction of an amine, an aldehyde or a ketone, and a di/trialkyl/aryl phosphite to form α …

Hypersialylation of tumor cell surface proteins along with a marked upregulation of
sialyltransferase (ST) activity is a well‐established hallmark of cancer. Due to the critical role …

Glycans, the carbohydrate chains of glycoproteins, proteoglycans, and glycolipids, represent
a relatively unexploited area for drug development compared with other macromolecules …

Published data on the synthesis, absolute configurations and biological properties of chiral
hydroxy phosphonates are generalised and described systematically. Examples of …