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Going circular: history, present, and future of circRNAs in cancer
To date, thousands of highly abundant and conserved single-stranded RNA molecules
shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional …
shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional …
Exosomal circular RNAs: a chief culprit in cancer chemotherapy resistance
Chemotherapy is one of the primary treatments for malignant tumors. However, the acquired
drug resistance hinders clinical efficacy and leads to treatment failure in most patients …
drug resistance hinders clinical efficacy and leads to treatment failure in most patients …
Circular RNA in cancer
Over the past decade, circular RNA (circRNA) research has evolved into a bona fide
research field shedding light on the functional consequence of this unique family of RNA …
research field shedding light on the functional consequence of this unique family of RNA …
Advancements of in vitro transcribed mRNA (IVT mRNA) to enable translation into the clinics
The accelerated progress and approval of two mRNA-based vaccines to address the SARS-
CoV-2 virus were unprecedented. This record-setting feat was made possible through the …
CoV-2 virus were unprecedented. This record-setting feat was made possible through the …
Regulation of microRNA by circular RNA
Circular (circ) RNAs have emerged as novel regulators of gene expression through various
mechanisms. However, most publications focus on functional circRNAs regulating target …
mechanisms. However, most publications focus on functional circRNAs regulating target …
Exosomal circRNAs: Novel biomarkers and therapeutic targets for urinary tumors
Q Liu, S Li - Cancer Letters, 2024 - Elsevier
Exosomal circRNAs have emerged as promising biomarkers and therapeutic targets for
urinary tumors. In this review, we explored the intricate role of exosomal circRNAs in …
urinary tumors. In this review, we explored the intricate role of exosomal circRNAs in …
Cellular trafficking of nanotechnology‐mediated mRNA delivery
P Huang, H Deng, C Wang, Y Zhou… - Advanced …, 2024 - Wiley Online Library
Messenger RNA (mRNA)‐based therapy has emerged as a powerful, safe, and rapidly
scalable therapeutic approach that involves technologies for both mRNA itself and the …
scalable therapeutic approach that involves technologies for both mRNA itself and the …
Optimal design of synthetic circular RNAs
SW Choi, JW Nam - Experimental & Molecular Medicine, 2024 - nature.com
Circular RNAs are an unusual class of single-stranded RNAs whose ends are covalently
linked via back-splicing. Due to their versatility, the need to express circular RNAs in vivo …
linked via back-splicing. Due to their versatility, the need to express circular RNAs in vivo …
Techniques for investigating lncRNA transcript functions in neurodevelopment
T Srinivas, E Siqueira, S Guil - Molecular Psychiatry, 2024 - nature.com
Long noncoding RNAs (lncRNAs) are sequences of 200 nucleotides or more that are
transcribed from a large portion of the mammalian genome. While hypothesized to have a …
transcribed from a large portion of the mammalian genome. While hypothesized to have a …
Approaches and challenges in genome-wide circular RNA identification and quantification
Numerous circular RNAs (circRNAs) produced from back-splicing of exon (s) have been
recently revealed on a genome-wide scale across species. Although generally expressed at …
recently revealed on a genome-wide scale across species. Although generally expressed at …