Biology of melanocytes in mammals

YZ Cui, XY Man - Frontiers in Cell and Developmental Biology, 2023 - frontiersin.org
Melanocytes, which originate from the neuroectoderm, are specialized cells responsible for
producing pigments and possessing a dendritic morphology. These cells migrate to the …

Recognition of melanocytes in immuno-neuroendocrinology and circadian rhythms: beyond the conventional melanin synthesis

YY Chen, LP Liu, H Zhou, YW Zheng, YM Li - Cells, 2022 - mdpi.com
Melanocytes produce melanin to protect the skin from UV-B radiation. Notwithstanding, the
spectrum of their functions extends far beyond their well-known role as melanin production …

Neural crest and sons: role of neural crest cells and Schwann cell precursors in development and gland embryogenesis

A Knyazeva, V Dyachuk - Frontiers in Cell and Developmental Biology, 2024 - frontiersin.org
In this review, we consider the multipotency of neural crest cells (NCCs), Schwann cell
precursors (SCPs), and their role in embryogenesis base on genetic tracing and knock out …

[HTML][HTML] Single-cell transcriptomic resolution of osteogenesis during craniofacial morphogenesis

E Hudacova, P Abaffy, MM Kaplan, M Krausova… - Bone, 2025 - Elsevier
Craniofacial morphogenesis depends on complex cell fate decisions during the
differentiation of post-migratory cranial neural crest cells. Molecular mechanisms of cell …

Intermediate cells of dual embryonic origin follow a basal to apical gradient of ingression into the lateral wall of the cochlea

JM Renauld, V Khan, ML Basch - Frontiers in Cell and …, 2022 - frontiersin.org
Intermediate cells of the stria vascularis are neural crest derived melanocytes. They are
essential for the establishment of the endocochlear potential in the inner ear, which allows …

Cell fate decisions in the neural crest, from pigment cell to neural development

JHP Dawes, RN Kelsh - International Journal of Molecular Sciences, 2021 - mdpi.com
The neural crest shows an astonishing multipotency, generating multiple neural derivatives,
but also pigment cells, skeletogenic and other cell types. The question of how this process is …

Generation of Pmel‐dependent conditional and inducible Cre‐driver mouse line for melanocytic‐targeted gene manipulation

M Nasrin, O Ahmed, X Han… - Pigment Cell & …, 2023 - Wiley Online Library
Conditional and inducible gene targeting using Cre/loxP‐mediated recombination is a
powerful reverse genetics approach used to study spatiotemporal gene functions in …

[HTML][HTML] Current Insights into the Role of UV Radiation-Induced Oxidative Stress in Melanoma Pathogenesis

E Gieniusz, E Skrzydlewska, W Łuczaj - International Journal of …, 2024 - mdpi.com
Cutaneous melanoma accounts for the majority of skin cancer-related deaths, and its
incidence increases each year. The growing number of melanoma cases, especially in …

NR2F1 regulates a Schwann cell precursor‐vs‐melanocyte cell fate switch in a mouse model of Waardenburg syndrome type IV

G Bonnamour, B Charrier, S Sallis… - Pigment Cell & …, 2022 - Wiley Online Library
Abstract Waardenburg syndrome type 4 (WS4) combines abnormal development of neural
crest cell (NCC)‐derived melanocytes (causing depigmentation and inner ear dysfunction) …

EGR3 Inhibits Tumor Progression by Inducing Schwann Cell‐Like Differentiation

C Chen, Y Chen, Y Li, H Zhang, X Huang… - Advanced …, 2024 - Wiley Online Library
The mechanism and function of the expression of Schwann characteristics by nevus cells in
the mature zone of the dermis are unknown. Early growth response 3 (EGR3) induces …