The emerging roles of circRNAs in cancer and oncology

LS Kristensen, T Jakobsen, H Hager… - Nature reviews Clinical …, 2022 - nature.com
Over the past decade, circular RNAs (circRNAs) have emerged as a large class of primarily
non-coding RNA molecules, many of which have key roles in cancer development and …

Biogenesis and regulatory roles of circular RNAs

L Yang, JE Wilusz, LL Chen - Annual review of cell and …, 2022 - annualreviews.org
Covalently closed, single-stranded circular RNAs can be produced from viral RNA genomes
as well as from the processing of cellular housekee** noncoding RNAs and precursor …

Circular RNA: metabolism, functions and interactions with proteins

WY Zhou, ZR Cai, J Liu, DS Wang, HQ Ju, RH Xu - Molecular cancer, 2020 - Springer
Abstract Circular RNAs (CircRNAs) are single-stranded, covalently closed RNA molecules
that are ubiquitous across species ranging from viruses to mammals. Important advances …

RNA in cancer

GJ Goodall, VO Wickramasinghe - Nature Reviews Cancer, 2021 - nature.com
While the processing of mRNA is essential for gene expression, recent findings have
highlighted that RNA processing is systematically altered in cancer. Mutations in RNA …

Circular RNA in cancer

VM Conn, AM Chinnaiyan, SJ Conn - Nature Reviews Cancer, 2024 - nature.com
Over the past decade, circular RNA (circRNA) research has evolved into a bona fide
research field shedding light on the functional consequence of this unique family of RNA …

Demethylase ALKBH5 suppresses invasion of gastric cancer via PKMYT1 m6A modification

Y Hu, C Gong, Z Li, J Liu, Y Chen, Y Huang, Q Luo… - Molecular cancer, 2022 - Springer
Background Gastric cancer (GC) is one of the most pernicious tumors that seriously harm
human healthcare. GC metastasis is one of the prime cause of failed cancer treatment, but …

Role of m6A writers, erasers and readers in cancer

Z Fang, W Mei, C Qu, J Lu, L Shang, F Cao… - … Hematology & Oncology, 2022 - Springer
Abstract The N (6)-methyladenosine (m6A) modification is the most pervasive modification of
human RNAs. In recent years, an increasing number of studies have suggested that m6A …

Going circular: history, present, and future of circRNAs in cancer

G Pisignano, DC Michael, TH Visal, R Pirlog… - Oncogene, 2023 - nature.com
To date, thousands of highly abundant and conserved single-stranded RNA molecules
shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional …

Hsa_circ_0003258 promotes prostate cancer metastasis by complexing with IGF2BP3 and sponging miR-653-5p

YZ Yu, DJ Lv, C Wang, XL Song, T **e, T Wang, ZM Li… - Molecular cancer, 2022 - Springer
Background More and more studies have shown that circular RNAs (circRNAs) play a critical
regulatory role in many cancers. However, the potential molecular mechanism of circRNAs …

RBM15 facilitates laryngeal squamous cell carcinoma progression by regulating TMBIM6 stability through IGF2BP3 dependent

X Wang, L Tian, Y Li, J Wang, B Yan, L Yang… - Journal of Experimental …, 2021 - Springer
Background Laryngeal cancer has the highest mortality rate among head and neck tumours.
RNA N6-methyladenosine (m6A) is the most plentiful and variable in mammalian mRNA …