Gastrointestinal stromal tumor (GIST) is the most common human sarcoma and usually
results from a sporadic mutation in KIT or, less frequently, platelet-derived growth factor …

Background The patient selection for optimal adjuvant therapy in gastrointestinal stromal
tumors (GISTs) is provided by nomogram based on tumor size, mitotic index, tumor location …

Advances in molecular genetics have revolutionized our understanding of the pathogenesis,
progression, and therapeutic options for treating gastrointestinal (GI) cancers. This chapter …

Background: The etiology of most mesenchymal tumors is unknown, and knowledge about
syndromes with an increased risk of tumors in bone or soft tissue is sparse. Methods: We …

Background Gastrointestinal stromal tumours (GISTs) are prevalent mesenchymal tumours
of the gastrointestinal tract, commonly exhibiting structural variations in KIT and PDGFRA …

Germline cancer predisposition is an important cause of premature mortality. Traditionally,
gene discovery in hereditary cancer involved either familial linkage analysis to segregate a …

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasm of
the digestive tract. Despite multiple therapeutic advances, patients with advanced disease …

Background Children, adolescents, and young adults (CAYA)(age≤ 39 years) with GIST
have high rates of LNM, but their clinical relevance is undefined. This study analyzed the …

Background Gastrointestinal stromal tumours (GIST) are tumours of the digestive tract that
mainly develop in adults. Recommendations for the management of GIST in pediatrics are …

Germline predisposing pathogenic variants (GPVs) are present in approximately 8–10% of
children with all cancer types. Very rare tumours (VRTs) represent many different diseases …