Cognitive impairment and neurodegenerative diseases development associated with organophosphate pesticides exposure: a review study

M Sarailoo, S Afshari, V Asghariazar, E Safarzadeh… - Neurotoxicity …, 2022 - Springer
A significant body of literature emphasizes the role of insecticide, particularly
organophosphates (OPs), as the major environmental factor in the etiology of …

How neurobehavior and brain development in alternative whole-organism models can contribute to prediction of developmental neurotoxicity

EMS Collins, EVS Hessel, S Hughes - Neurotoxicology, 2024 - Elsevier
Developmental neurotoxicity (DNT) is not routinely evaluated in chemical risk assessment
because current test paradigms for DNT require the use of mammalian models which are …

[HTML][HTML] Organophosphate toxicity patterns: A new approach for assessing organophosphate neurotoxicity

S Karaboga, F Severac, EMS Collins, A Stab… - Journal of Hazardous …, 2024 - Elsevier
Organophosphorus compounds or organophosphates (OPs) are widely used as flame
retardants, plasticizers, lubricants and pesticides. This contributes to their ubiquitous …

Neuropsychiatric disorders in farmers associated with organophosphorus pesticide exposure in a rural village of Northwest México

A Serrano-Medina, A Ugalde-Lizárraga… - International journal of …, 2019 - mdpi.com
This study aims to determine the degree of acetylcholinesterase inhibition and neurological
symptoms for each of the psychiatric disorders diagnosed in the farm workers of a rural …

Differences in neurotoxic outcomes of organophosphorus pesticides revealed via multi-dimensional screening in adult and regenerating planarians

D Ireland, S Zhang, V Bochenek, JH Hsieh… - Frontiers in …, 2022 - frontiersin.org
Organophosphorus pesticides (OPs) are a chemically diverse class of commonly used
insecticides. Epidemiological studies suggest that low dose chronic prenatal and infant …

Dugesia japonica is the best suited of three planarian species for high-throughput toxicology screening

D Ireland, V Bochenek, D Chaiken, C Rabeler, S Onoe… - Chemosphere, 2020 - Elsevier
High-throughput screening (HTS) using new approach methods is revolutionizing
toxicology. Asexual freshwater planarians are a promising invertebrate model for …

[HTML][HTML] PBDEs disrupt homeostasis maintenance and regeneration of planarians due to DNA damage, proliferation and apoptosis anomaly

Y Yang, L Wang, Y Zhao, F Ma, Z Lin, Y Liu… - Ecotoxicology and …, 2022 - Elsevier
Polybrominated diphenyl ethers (PBDEs) are widely used as brominated flame retardants in
the manufacturing industry, belonging to persistent organic pollutants in the environment …

Screening for neurotoxic potential of 15 flame retardants using freshwater planarians

S Zhang, D Ireland, NS Sipes, M Behl… - Neurotoxicology and …, 2019 - Elsevier
Asexual freshwater planarians are an attractive invertebrate model for high-throughput
neurotoxicity screening, because they possess multiple quantifiable behaviors to assess …

New worm on the block: Planarians in (neuro) toxicology

D Ireland, EMS Collins - Current protocols, 2022 - Wiley Online Library
Traditional mammalian testing is too time‐and cost‐intensive to keep up with the large
number of environmental chemicals needing assessment. This has led to a dearth of …

Beyond the behavioural phenotype: Uncovering mechanistic foundations in aquatic eco-neurotoxicology

D Wlodkowic, A Bownik, C Leitner, D Stengel… - Science of The Total …, 2022 - Elsevier
During the last decade, there has been an increase in awareness of how anthropogenic
pollution can alter behavioural traits of diverse aquatic organisms. Apart from understanding …