2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: Developed by the task force for the …

K Zeppenfeld, J Tfelt-Hansen, M De Riva… - European heart …, 2022‏ - academic.oup.com
4004 ESC Guidelines label use of medication should be limited to situations where it is in
the patient's interest to do so, with regard to the quality, safety, and efficacy of care, and only …

Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications

CC Jiang, LS Lin, S Long, XY Ke, K Fukunaga… - Signal transduction and …, 2022‏ - nature.com
Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …

Antisense oligonucleotide therapeutic approach for Timothy syndrome

X Chen, F Birey, MY Li, O Revah, R Levy, MV Thete… - Nature, 2024‏ - nature.com
Timothy syndrome (TS) is a severe, multisystem disorder characterized by autism, epilepsy,
long-QT syndrome and other neuropsychiatric conditions. TS type 1 (TS1) is caused by a …

Assembly of functionally integrated human forebrain spheroids

F Birey, J Andersen, CD Makinson, S Islam, W Wei… - Nature, 2017‏ - nature.com
The development of the nervous system involves a coordinated succession of events
including the migration of GABAergic (γ-aminobutyric-acid-releasing) neurons from ventral …

Calcium channels, synaptic plasticity, and neuropsychiatric disease

E Nanou, WA Catterall - Neuron, 2018‏ - cell.com
Voltage-gated calcium channels couple depolarization of the cell-surface membrane to entry
of calcium, which triggers secretion, contraction, neurotransmission, gene expression, and …

Calcium signaling and cardiac arrhythmias

AP Landstrom, D Dobrev, XHT Wehrens - Circulation research, 2017‏ - ahajournals.org
There has been a significant progress in our understanding of the molecular mechanisms by
which calcium (Ca2+) ions mediate various types of cardiac arrhythmias. A growing list of …

The physiology, pathology, and pharmacology of voltage-gated calcium channels and their future therapeutic potential

GW Zamponi, J Striessnig, A Koschak… - Pharmacological …, 2015‏ - Elsevier
Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …

[HTML][HTML] Neuronal voltage-gated calcium channels: structure, function, and dysfunction

BA Simms, GW Zamponi - Neuron, 2014‏ - cell.com
Voltage-gated calcium channels are the primary mediators of depolarization-induced
calcium entry into neurons. There is great diversity of calcium channel subtypes due to …

Targeting voltage-gated calcium channels in neurological and psychiatric diseases

GW Zamponi - Nature reviews Drug discovery, 2016‏ - nature.com
Voltage-gated calcium channels are important regulators of brain, heart and muscle
functions, and their dysfunction can give rise to pathophysiological conditions ranging from …

The genomic landscape of balanced cytogenetic abnormalities associated with human congenital anomalies

C Redin, H Brand, RL Collins, T Kammin, E Mitchell… - Nature …, 2017‏ - nature.com
Despite the clinical significance of balanced chromosomal abnormalities (BCAs), their
characterization has largely been restricted to cytogenetic resolution. We explored the …