Outcomes of neonatal encephalopathy (NE) have improved since the widespread
implementation of therapeutic hypothermia (TH) in high-resource settings. While TH for NE …

Neonatal seizures constitute the most frequent presenting neurologic sign encountered in
the neonatal intensive care unit. Despite limited efficacy and safety data, phenobarbital …

METHODS: The study was a multicenter, randomized, blinded, controlled, phase IIb trial
investigating the efficacy and safety of levetiracetam compared with phenobarbital as a first …

Objective: Drug exposure during critical periods of brain development may adversely affect
nervous system function, posing a challenge for treating infants. This is of particular concern …

Neonatal neurocritical intensive care is dedicated to safeguarding the newborn brain by
prioritising clinical practices that promote early identification, diagnosis and treatment of …

Objective During critical periods of brain development, both seizures and anticonvulsant
medications can affect neurodevelopmental outcomes. In rodent models, many …

The risk of seizures is at its highest during the neonatal period, and the most common cause
of neonatal seizures is hypoxic–ischaemic encephalopathy (HIE). This enhanced …

New neurons are generated in the hippocampal dentate gyrus from early development
through adulthood. Progenitor cells and immature granule cells in the subgranular zone are …

A significant proportion of neonatal and childhood seizures are poorly controlled by existing
anti-seizure drugs (ASDs), likely due to prominent differences in ionic homeostasis and …

Increasing evidence suggests that exposure to certain antiepileptic drugs (AEDs) during
critical periods of development may induce transient or long-lasting neurodevelopmental …