Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

MC Field, D Horn, AH Fairlamb… - Nature Reviews …, 2017 - nature.com
The WHO recognizes human African trypanosomiasis, Chagas disease and the
leishmaniases as neglected tropical diseases. These diseases are caused by parasitic …

Glycomics, glycoproteomics, and glycogenomics: an inter-taxa evolutionary perspective

CM West, D Malzl, A Hykollari, IBH Wilson - Molecular & Cellular …, 2021 - ASBMB
Glycosylation is a highly diverse set of co-and posttranslational modifications of proteins. For
mammalian glycoproteins, glycosylation is often site-, tissue-, and species-specific and …

Parasite glycobiology: a bittersweet symphony

JA Rodrigues, A Acosta-Serrano, M Aebi… - PLoS …, 2015 - journals.plos.org
Human infections caused by parasitic protozoans and helminths are among the world's
leading causes of death. More than a million people die each year from diseases like …

Comparisons of N-glycans across invertebrate phyla

K Paschinger, IBH Wilson - Parasitology, 2019 - cambridge.org
Many invertebrates are either parasites themselves or vectors involved in parasite
transmission; thereby, the interactions of parasites with final or intermediate hosts are often …

Glycans in the roles of parasitological diagnosis and host–parasite interplay

CDM Veríssimo, C Graeff-Teixeira, MK Jones… - Parasitology, 2019 - cambridge.org
The investigation of the glycan repertoire of several organisms has revealed a wide variation
in terms of structures and abundance of glycan moieties. Among the parasites, it is possible …

An essential, kinetoplastid-specific GDP-Fuc: β-D-Gal α-1, 2-fucosyltransferase is located in the mitochondrion of Trypanosoma brucei

G Bandini, S Damerow, MLS Guther, H Guo, A Mehlert… - Elife, 2021 - elifesciences.org
Fucose is a common component of eukaryotic cell-surface glycoconjugates, generally
added by Golgi-resident fucosyltransferases. Whereas fucosylated glycoconjugates are rare …

A Trypanosoma brucei β3 glycosyltransferase superfamily gene encodes a β1-6 GlcNAc-transferase mediating N-glycan and GPI anchor modification

SM Duncan, R Nagar, M Damerow… - Journal of Biological …, 2021 - ASBMB
The parasite Trypanosoma brucei exists in both a bloodstream form (BSF) and a procyclic
form (PCF), which exhibit large carbohydrate extensions on the N-linked glycans and …

Identification of a glycosylphosphatidylinositol anchor-modifying β1-3 galactosyltransferase in Trypanosoma brucei

L Izquierdo, A Acosta-Serrano, A Mehlert… - …, 2015 - academic.oup.com
Trypanosoma brucei is the causative agent of human African slee** sickness and the
cattle disease nagana. Trypanosoma brucei is dependent on glycoproteins for its survival …

Single-subunit oligosaccharyltransferases of Trypanosoma brucei display different and predictable peptide acceptor specificities

A **nelov, L Ali, M Tinti, MLS Güther… - Journal of Biological …, 2017 - ASBMB
Trypanosoma brucei causes African trypanosomiasis and contains three full-length
oligosaccharyltransferase (OST) genes; two of which, TbSTT3A and TbSTT3B, are …

A gene of the β3-glycosyltransferase family encodes N-acetylglucosaminyltransferase II function in Trypanosoma brucei

M Damerow, F Graalfs, MLS Güther, A Mehlert… - Journal of Biological …, 2016 - ASBMB
The bloodstream form of the human pathogen Trypanosoma brucei expresses
oligomannose, paucimannose, and complex N-linked glycans, including some exceptionally …