Orofacial clefts are common birth defects and can occur as isolated, nonsyndromic events or
as part of Mendelian syndromes. There is substantial phenotypic diversity in individuals with …

Orofacial clefts are the most common craniofacial birth defects and one of the most common
congenital malformations in humans. They require complex multidisciplinary treatment and …

Upstream open reading frames (uORFs) are tissue-specific cis-regulators of protein
translation. Isolated reports have shown that variants that create or disrupt uORFs can cause …

Mutations in interferon regulatory factor 6 (IRF6) account for∼ 70% of cases of Van der
Woude syndrome (VWS), the most common syndromic form of cleft lip and palate. In 8 of 45 …

Diverse signaling cues and attendant proteins work together during organogenesis,
including craniofacial development. Lip and palate formation starts as early as the fourth …

Cleft of the lip with or without cleft palate (CL/P) represents one of the commonest congenital
malformations in Western countries. Based on their association with specific malformative …

The likelihood of birth defects in orofacial tissues is high due to the structural and
developmental complexity of the face and the susceptibility to intrinsic and extrinsic …

Programmed RNA editing presents an attractive therapeutic strategy for genetic disease. In
this study, we developed bacterial deaminase-enabled recoding of RNA (DECOR), which …

Cleft palate is a common congenital disorder that affects up to 1 in 2,500 live human births
and results in considerable morbidity to affected individuals and their families. The etiology …

Tooth agenesis and orofacial clefts represent the most common developmental anomalies
and their co-occurrence is often reported in patients as well in animal models. The aim of the …