Gut microbiota-derived metabolites as key actors in inflammatory bowel disease

A Lavelle, H Sokol - Nature reviews Gastroenterology & hepatology, 2020‏ - nature.com
A key role of the gut microbiota in the establishment and maintenance of health, as well as in
the pathogenesis of disease, has been identified over the past two decades. One of the …

Gut microbiome, metabolome, host immunity associated with inflammatory bowel disease and intervention of fecal microbiota transplantation

R Wu, R **ong, Y Li, J Chen, R Yan - Journal of autoimmunity, 2023‏ - Elsevier
Gut dysbiosis has been associated with inflammatory bowel disease (IBD), one of the most
common gastrointestinal diseases. The microbial communities play essential roles in host …

Human metabolome variation along the upper intestinal tract

J Folz, RN Culver, JM Morales, J Grembi… - Nature …, 2023‏ - nature.com
Most processing of the human diet occurs in the small intestine. Metabolites in the small
intestine originate from host secretions, plus the ingested exposome and microbial …

Drivers and determinants of strain dynamics following fecal microbiota transplantation

TSB Schmidt, SS Li, OM Maistrenko, W Akanni… - Nature Medicine, 2022‏ - nature.com
Fecal microbiota transplantation (FMT) is a therapeutic intervention for inflammatory
diseases of the gastrointestinal tract, but its clinical mode of action and subsequent …

Gut microbiota in ulcerative colitis: insights on pathogenesis and treatment

XY Guo, XJ Liu, JY Hao - Journal of digestive diseases, 2020‏ - Wiley Online Library
Gut microbiota constitute the largest reservoir of the human microbiome and are an
abundant and stable ecosystem—based on its diversity, complexity, redundancy, and host …

[HTML][HTML] Fecal microbial and metabolic profiles in dogs with acute diarrhea receiving either fecal microbiota transplantation or oral metronidazole

J Chaitman, AL Ziese, R Pilla, Y Minamoto… - Frontiers in veterinary …, 2020‏ - frontiersin.org
The aim was to characterize differences in fecal consistency, and fecal microbiota and
metabolome profiles in dogs with acute diarrhea (AD) treated with either fecal microbiota …

Protective effect of baicalin on the regulation of Treg/Th17 balance, gut microbiota and short-chain fatty acids in rats with ulcerative colitis

L Zhu, LZ Xu, S Zhao, ZF Shen, H Shen… - Applied Microbiology and …, 2020‏ - Springer
Baicalin is reported as an effective drug for ulcerative colitis (UC). However, its effect on gut
microbiota and short-chain fatty acids (SCFAs) remains unknown. In this study, we …

[HTML][HTML] Gut microbiota in pathophysiology, diagnosis, and therapeutics of inflammatory bowel disease

H Pandey, D Jain, DWT Tang, SH Wong… - Intestinal …, 2024‏ - synapse.koreamed.org
Inflammatory bowel disease (IBD) is a multifactorial disease, which is thought to be an
interplay between genetic, environment, microbiota, and immune-mediated factors …

[HTML][HTML] Metabolome analysis for investigating host-gut microbiota interactions

MX Chen, SY Wang, CH Kuo, IL Tsai - Journal of the Formosan Medical …, 2019‏ - Elsevier
Dysbiosis of the gut microbiome is associated with host health conditions. Many diseases
have shown to have correlations with imbalanced microbiota, including obesity …

Microbiota changes and intestinal microbiota transplantation in liver diseases and cirrhosis

JS Bajaj, A Khoruts - Journal of hepatology, 2020‏ - Elsevier
Patients with chronic liver disease and cirrhosis demonstrate a global mucosal immune
impairment, which is associated with altered gut microbiota composition and functionality …