The best-known role of UDP-glucuronosyltransferase enzymes (UGTs) in cancer is the
metabolic inactivation of drug therapies. By conjugating glucuronic acid to lipophilic drugs …

Huggins and Hodges demonstrated the therapeutic effect of gonadal testosterone
deprivation in the 1940s and therefore firmly established the concept that prostate cancer is …

Abstract Androgen receptor-(AR-) indifference is a mechanism of resistance to hormonal
therapy in prostate cancer (PC). Here we demonstrate that ONECUT2 (OC2) activates …

Prostate cancer is highly dependent on androgens and the androgen receptor (AR).
Hormonal therapies inhibit gonadal testosterone production, block extragonadal androgen …

Prostate cancer ranks as one of the most diagnosed and challenging malignancies affecting
individuals worldwide. For hormone-dependent prostate cancer treatment Gonadotropin …

After androgen deprivation, prostate cancer frequently becomes castration resistant (CRPC),
with intratumoral androgen production from extragonadal precursors that activate the …

The prostate is an androgen-dependent organ that develops only in male mammals.
Prostate cancer is the most common nonskin malignancy in men and the second leading …

Melanoma incidence and mortality rates are historically higher for men than women.
Although emerging studies have highlighted tumorigenic roles for the male sex hormone …

Androgens play an essential role in prostate cancer. Clinical treatments that target
steroidogenesis and the androgen receptor (AR) successfully postpone disease …

The UDP glycosyltransferase (UGT) superfamily of enzymes is responsible for the
metabolism and clearance of thousands of lipophilic chemicals including drugs, toxins and …