Hypoxia represents a frequent player in a number of malignancies, contributing to the
development of the neoplastic disease. This review will discuss the means by which hypoxia …

Nrf2 is a transcription factor that stimulates the expression of genes which have antioxidant
response element-like sequences in their promoter. Nrf2 is a cellular protector, and this …

Even though the inevitable process of aging by itself cannot be considered a disease, it is
directly linked to life span and is the driving force behind all age-related diseases. It is an …

Our knowledge of the effect of metformin on human health is increasing. In addition to its
ability to improve the control of hyperglycaemia, metformin has been shown to reduce the …

Worldwide, breast cancer (BC) is the most common malignancy in women, in regard to
incidence and mortality. In recent years, the negative role of obesity during BC development …

Due to the huge costs associated with new drug discovery and development, drug
repurposing has become an important complement to the traditional de novo approach. With …

Sirtuin-1 deacetylates proteins and has emerged as a critical regulator of different cellular
processes, particularly inflammation. Basal SIRT1 activity was previously found to limit Th9 …

Due to the high number of annual cancer–related deaths, and the economic burden that this
malignancy affects today's society, the study of compounds isolated from natural sources …

Metformin is one of the most commonly used first-line oral medications for type 2 diabetes
mellitus. Multiple observational studies, reviewed in numerous systematic reviews, have …

Mycobacterium tuberculosis has succeeded in infecting one-third of the human race though
inhibition or evasion of innate and adaptive immunity. The pathogen is a facultative …